HOXA10 expression in ectopic endometrial tissue

被引:50
作者
Browne, Hyacinth [1 ]
Taylor, Hugh [1 ]
机构
[1] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, New Haven, CT 06520 USA
关键词
endometriosis; HOX; homeobox genes; implantation; HOXA10; endometrium;
D O I
10.1016/j.fertnstert.2005.10.072
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To evaluate HOXA10 expression in endometriosis. Design: Laboratory study using human tissue. Setting: Academic research center. Patient(s): Eutopic endometrial tissue was collected from 20 fertile women without endometriosis. Ectopic endometrial tissues from pelvic peritoneum, ovary, and lung parenchyma were collected from 20 women undergoing surgery for endometriosis. Intervention(s): HOXA10 protein expression and localization with immunohistochemistry. Main Outcome Measure(s): Quantitative analysis of HOXA10 expression, according to H score. Results(s): Both eutopic and ectopic endometrial tissue expressed HOXA10. Ectopic endometrial tissue had lower stromal HOXA10 expression compared with eutopic endometrium. The mean H score for stromal expression of HOXA10 was 7.6 in eutopic endometrium and 1.3 in ectopic endometrial tissue. Glandular epithelium from both eutopic and ectopic endometrium had similarly low HOXA10 expression. HOXA10 was also expressed at low levels in lung parenchyma containing endometriosis and in ovarian endometriomas. Conclusion(S): HOXA10 is expressed in endometriosis at locations outside of the normal HOXA10 expression domain, where it is likely necessary to impart endometrial developmental identity on endometriosis. HOXA W might be necessary for "de novo" endometrial development. However, the diminished expression of HOXA10 in ectopic endometrium might not allow for normal endometrial development and might contribute to the pathogenesis of endometriosis by creating P resistance.
引用
收藏
页码:1386 / 1390
页数:5
相关论文
共 30 条
[1]   The effect of endometriosis on implantation: Results from the Yale University in vitro fertilization and embryo transfer program [J].
Arici, A ;
Oral, E ;
Bukulmez, O ;
Duleba, A ;
Olive, DL ;
Jones, EE .
FERTILITY AND STERILITY, 1996, 65 (03) :603-607
[2]   Progesterone receptor isoform A but not B is expressed in endometriosis [J].
Attia, GR ;
Zeitoun, K ;
Edwards, D ;
Johns, A ;
Carr, BR ;
Bulun, SE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (08) :2897-2902
[3]   Effect of endometriosis on in vitro fertilization [J].
Barnhart, K ;
Dunsmoor-Su, R ;
Coutifaris, C .
FERTILITY AND STERILITY, 2002, 77 (06) :1148-1155
[4]  
Benson GV, 1996, DEVELOPMENT, V122, P2687
[5]   Quantitative enzyme immunoassay and semiquantitative immunohistochemistry of oestrogen and progesterone receptors in endometriotic tissue and endometrium [J].
Bergqvist, A ;
Ferno, M ;
Skoog, L .
JOURNAL OF CLINICAL PATHOLOGY, 1997, 50 (06) :496-500
[6]  
Bulun SE, 2004, SEMIN REPROD MED, V22, P45
[7]   Pleiotropic effects of Hoxa10 on the functional development of peri-implantation endometrium [J].
Daftary, GS ;
Taylor, HS .
MOLECULAR REPRODUCTION AND DEVELOPMENT, 2004, 67 (01) :8-14
[8]   Implantation in the human: The role of HOX genes [J].
Daftary, GS ;
Taylor, HS .
SEMINARS IN REPRODUCTIVE MEDICINE, 2000, 18 (03) :311-320
[9]   Epidemiology of endometriosis [J].
Eskenazi, B ;
Warner, ML .
OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 1997, 24 (02) :235-+
[10]   Endometriosis [J].
Giudice, LC ;
Kao, LC .
LANCET, 2004, 364 (9447) :1789-1799