Infectivity, Transmission, and Pathology of Human-Isolated H7N9 Influenza Virus in Ferrets and Pigs

被引：279

作者：

Zhu, H. ^{[1
,2
,3
]}

Wang, D. ^{[8
]}

Kelvin, D. J. ^{[4
,5
,6
]}

Li, L. ^{[1
]}

Zheng, Z. ^{[1
]}

Yoon, S. -W. ^{[7
]}

Wong, S. -S. ^{[7
]}

Farooqui, A. ^{[4
]}

Wang, J. ^{[1
,3
]}

Banner, D. ^{[5
]}

Chen, R. ^{[1
]}

Zheng, R. ^{[1
]}

Zhou, J. ^{[1
,2
,3
]}

Zhang, Y. ^{[1
]}

Hong, W. ^{[1
]}

Dong, W. ^{[4
]}

Cai, Q. ^{[1
]}

Roehrl, M. H. A. ^{[5
,6
]}

Huang, S. S. H. ^{[5
,6
]}

Kelvin, A. A. ^{[4
,5
]}

Yao, T. ^{[1
]}

Zhou, B. ^{[2
]}

Chen, X. ^{[2
]}

Leung, G. M. ^{[3
]}

Poon, L. L. M. ^{[2
,3
]}

Webster, R. G. ^{[7
]}

Webby, R. J. ^{[7
]}

Peiris, J. S. M. ^{[2
,3
]}

Guan, Y. ^{[1
,2
,3
]}

Shu, Y.

机构：

[1] Shantou Univ, Joint Influenza Res Ctr SUMC HKU, Shantou, Peoples R China

[2] Shenzhen Third Peoples Hosp, State Key Lab Emerging Infect Dis, HKU Shenzhen Branch, Shenzhen, Peoples R China

[3] Univ Hong Kong, Sch Publ Hlth, Influenza Res Ctr, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China

[4] Shantou Univ Med Coll, Joint Vaccine Res Ctr SUMC UHN, Shantou, Peoples R China

[5] Univ Hlth Network, Toronto, ON, Canada

[6] Univ Toronto, Toronto, ON, Canada

[7] St Jude Childrens Res Hosp, Dept Infect Dis, Div Virol, Memphis, TN 38105 USA

[8] Natl Hlth & Family Planning Commiss, Natl Inst Viral Dis Control & Prevent, Chinese Ctr Dis Control & Prevent, Key Lab Med Virol, Beijing, Peoples R China

来源：

SCIENCE | 2013年 / 341卷 / 6142期

关键词：

PATHOGENESIS; EVOLUTION;

D O I：

10.1126/science.1239844

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The emergence of the H7N9 influenza virus in humans in Eastern China has raised concerns that a new influenza pandemic could occur. Here, we used a ferret model to evaluate the infectivity and transmissibility of A/Shanghai/2/2013 (SH2), a human H7N9 virus isolate. This virus replicated in the upper and lower respiratory tracts of the ferrets and was shed at high titers for 6 to 7 days, with ferrets showing relatively mild clinical signs. SH2 was efficiently transmitted between ferrets via direct contact, but less efficiently by airborne exposure. Pigs were productively infected by SH2 and shed virus for 6 days but were unable to transmit the virus to naive pigs or ferrets. Under appropriate conditions, human-to-human transmission of the H7N9 virus may be possible.

引用

页码：183 / 186

页数：4

共 16 条

[1] Pathogenesis of Influenza A/H5N1 Virus Infection in Ferrets Differs between Intranasal and Intratracheal Routes of Inoculation [J].

Bodewes, Rogier ;

Kreijtz, Joost H. C. M. ;

van Amerongen, Geert ;

Fouchier, Ron A. M. ;

Osterhaus, Albert D. M. E. ;

Rimmelzwaan, Guus F. ;

Kuiken, Thijs .

AMERICAN JOURNAL OF PATHOLOGY, 2011, 179 (01) :30-36

[2] RECEPTOR SPECIFICITY IN HUMAN, AVIAN, AND EQUINE H2 AND H3 INFLUENZA-VIRUS ISOLATES [J].

CONNOR, RJ ;

KAWAOKA, Y ;

WEBSTER, RG ;

PAULSON, JC .

VIROLOGY, 1994, 205 (01) :17-23

[3] Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus [J].

Gao, Rongbao ;

Cao, Bin ;

Hu, Yunwen ;

Feng, Zijian ;

Wang, Dayan ;

Hu, Wanfu ;

Chen, Jian ;

Jie, Zhijun ;

Qiu, Haibo ;

Xu, Ke ;

Xu, Xuewei ;

Lu, Hongzhou ;

Zhu, Wenfei ;

Gao, Zhancheng ;

Xiang, Nijuan ;

Shen, Yinzhong ;

He, Zebao ;

Gu, Yong ;

Zhang, Zhiyong ;

Yang, Yi ;

Zhao, Xiang ;

Zhou, Lei ;

Li, Xiaodan ;

Zou, Shumei ;

Zhang, Ye ;

Li, Xiyan ;

Yang, Lei ;

Guo, Junfeng ;

Dong, Jie ;

Li, Qun ;

Dong, Libo ;

Zhu, Yun ;

Bai, Tian ;

Wang, Shiwen ;

Hao, Pei ;

Yang, Weizhong ;

Zhang, Yanping ;

Han, Jun ;

Yu, Hongjie ;

Li, Dexin ;

Gao, George F. ;

Wu, Guizhen ;

Wang, Yu ;

Yuan, Zhenghong ;

Shu, Yuelong .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (20) :1888-1897

[4] H7N9 Incident, immune status, the elderly and a warning of an influenza pandemic [J].

Guan, Yi ;

Farooqui, Amber ;

Zhu, Huachen ;

Dong, Wei ;

Wang, Jia ;

Kelvin, David J. .

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2013, 7 (04) :302-307

[5] In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses [J].

Itoh, Yasushi ;

Shinya, Kyoko ;

Kiso, Maki ;

Watanabe, Tokiko ;

Sakoda, Yoshihiro ;

Hatta, Masato ;

Muramoto, Yukiko ;

Tamura, Daisuke ;

Sakai-Tagawa, Yuko ;

Noda, Takeshi ;

Sakabe, Saori ;

Imai, Masaki ;

Hatta, Yasuko ;

Watanabe, Shinji ;

Li, Chengjun ;

Yamada, Shinya ;

Fujii, Ken ;

Murakami, Shin ;

Imai, Hirotaka ;

Kakugawa, Satoshi ;

Ito, Mutsumi ;

Takano, Ryo ;

Iwatsuki-Horimoto, Kiyoko ;

Shimojima, Masayuki ;

Horimoto, Taisuke ;

Goto, Hideo ;

Takahashi, Kei ;

Makino, Akiko ;

Ishigaki, Hirohito ;

Nakayama, Misako ;

Okamatsu, Masatoshi ;

Takahashi, Kazuo ;

Warshauer, David ;

Shult, Peter A. ;

Saito, Reiko ;

Suzuki, Hiroshi ;

Furuta, Yousuke ;

Yamashita, Makoto ;

Mitamura, Keiko ;

Nakano, Kunio ;

Nakamura, Morio ;

Brockman-Schneider, Rebecca ;

Mitamura, Hiroshi ;

Yamazaki, Masahiko ;

Sugaya, Norio ;

Suresh, M. ;

Ozawa, Makoto ;

Neumann, Gabriele ;

Gern, James ;

Kida, Hiroshi .

NATURE, 2009, 460 (7258) :1021-U110

[6]

Kageyama T, 2013, EUROSURVEILLANCE, V18, P7

[7] Epidemiology of Human Infections with Avian Influenza A(H7N9) Virus in China [J].

Li, Qun ;

Zhou, Lei ;

Zhou, Minghao ;

Chen, Zhiping ;

Li, Furong ;

Wu, Huanyu ;

Xiang, Nijuan ;

Chen, Enfu ;

Tang, Fenyang ;

Wang, Dayan ;

Meng, Ling ;

Hong, Zhiheng ;

Tu, Wenxiao ;

Cao, Yang ;

Li, Leilei ;

Ding, Fan ;

Liu, Bo ;

Wang, Mei ;

Xie, Rongheng ;

Gao, Rongbao ;

Li, Xiaodan ;

Bai, Tian ;

Zou, Shumei ;

He, Jun ;

Hu, Jiayu ;

Xu, Yangting ;

Chai, Chengliang ;

Wang, Shiwen ;

Gao, Yongjun ;

Jin, Lianmei ;

Zhang, Yanping ;

Luo, Huiming ;

Yu, Hongjie ;

He, Jianfeng ;

Li, Qi ;

Wang, Xianjun ;

Gao, Lidong ;

Pang, Xinghuo ;

Liu, Guohua ;

Yan, Yansheng ;

Yuan, Hui ;

Shu, Yuelong ;

Yang, Weizhong ;

Wang, Yu ;

Wu, Fan ;

Uyeki, Timothy M. ;

Feng, Zijian .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (06) :520-532

[8] The ferret: An animal model to study influenza virus [J].

Maher, JA ;

DeStefano, J .

LAB ANIMAL, 2004, 33 (09) :50-+

[9] Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model [J].

Maines, Taronna R. ;

Chen, Li-Mei ;

Matsuoka, Yumiko ;

Chen, Hualan ;

Rowe, Thomas ;

Ortin, Juan ;

Falcon, Ana ;

Hien, Nguyen Tran ;

Mai, Le Quynh ;

Sedyaningsih, Endang R. ;

Harun, Syahrial ;

Tumpey, Terrence M. ;

Donis, Ruben O. ;

Cox, Nancy J. ;

Subbarao, Kanta ;

Katz, Jacqueline M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (32) :12121-12126

[10] Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice [J].

Maines, Taronna R. ;

Jayaraman, Akila ;

Belser, Jessica A. ;

Wadford, Debra A. ;

Pappas, Claudia ;

Zeng, Hui ;

Gustin, Kortney M. ;

Pearce, Melissa B. ;

Viswanathan, Karthik ;

Shriver, Zachary H. ;

Raman, Rahul ;

Cox, Nancy J. ;

Sasisekharan, Ram ;

Katz, Jacqueline M. ;

Tumpey, Terrence M. .

SCIENCE, 2009, 325 (5939) :484-487

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