Expression of 25-hydroxyvitamin D3-1α-hydroxylase in subcutaneous fat necrosis

被引：37

作者：

Farooque, A. ^{[1
]}

Moss, C. ^{[2
]}

Zehnder, D. ^{[3
]}

Hewison, M. ^{[3
]}

Shaw, N. J. ^{[1
]}

机构：

[1] Birmingham Childrens Hosp, Dept Endocrinol, Birmingham B4 6NH, W Midlands, England

[2] Birmingham Childrens Hosp, Dept Dermatol, Birmingham B4 6NH, W Midlands, England

[3] Univ Birmingham, Div Med Sci, Birmingham B15 2TT, W Midlands, England

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2009年 / 160卷 / 02期

关键词：

hypercalcaemia; subcutaneous fat necrosis; vitamin D; VITAMIN-D; HYPERCALCEMIA; 1-ALPHA-HYDROXYLASE; NEWBORN;

D O I：

10.1111/j.1365-2133.2008.08844.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

The most serious complication of subcutaneous fat necrosis (SCFN), a rare condition of the newborn characterized by indurated purple nodules, is hypercalcaemia. However, the mechanism for this hypercalcaemia remains unclear. To determine whether the hypercalcaemia associated with SCFN involves expression of the vitamin D-activating enzyme 25-hydroxyvitamin D-3-1 alpha-hydroxylase (1 alpha-hydroxylase) in affected tissue. Skin biopsies from two male patients with SCFN and hypercalcaemia were taken. The histological specimens were assessed using a polyclonal antibody against 1 alpha-hydroxylase. Histology in both cases showed strong expression of 1 alpha-hydroxylase protein (brown staining) within the inflammatory infiltrate associated with SCFN. This was consistent with similar experiments in other granulomatous conditions. Hypercalcaemia in SCFN appears to be due to abundant levels of 1 alpha-hydroxylase in immune infiltrates associated with tissue lesions. This is consistent with previous observations of extrarenal 1 alpha-hydroxylase in skin from other granulomatous conditions such as sarcoidosis and slack skin disease.

引用

页码：423 / 425

页数：3

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