The hyaluronan receptor, CD44

被引：185

作者：

Isacke, CM

Yarwood, H

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biol, London SW7 2AZ, England

[2] Inst Canc Res, Chester Beatty Labs, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2002年 / 34卷 / 07期

关键词：

CD44; MMP; hyaluronan; motility;

D O I：

10.1016/S1357-2725(01)00166-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events. This has important implication for understanding how mis-regulation of CD44 can contribute to disease pathologies. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：718 / 721

页数：4

共 19 条

[1] Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid [J].