L-arginine supplementation improves venous endothelial cell but not smooth muscle cell dysfunction induced by prolonged diet-induced hypercholesterolemia

被引:11
作者
Davies, MG [1 ]
Barber, E [1 ]
Dalen, H [1 ]
Hagen, PO [1 ]
机构
[1] DUKE UNIV,MED CTR,DEPT BIOCHEM,VASC BIOL & ATHEROSCLEROSIS RES LAB,DURHAM,NC 27710
关键词
endothelial cell; hypercholesterolemia; L-arginine; rabbit; smooth muscle cell; vasomotor function; vein;
D O I
10.3109/08941939609025858
中图分类号
R61 [外科手术学];
学科分类号
摘要
Hypercholesterolemia induces venous vasomotor dysfunction. This study examines the endothelial and smooth muscle cell vasoreactivity of external jugular veins from rabbits fed either a normal or a 1% cholesterol diet for 8 weeks with and without L-arginine supplementation (2g/kg day(-1) orally for the last 5 weeks). Isometric tension studies were performed on harvested jugular veins. Concentrations of serum cholesterol were 20-fold higher than controls and serum L-arginine twofold higher than untreated animals. Hypercholesterolemia induced hypersensitivity to norepinephrine (p < .05), bradykinin (p < .05), and histamine (p < .05) with a contractile response to serotonin compared to controls. L-Arginine supplementation decreased bradykinin hypersensitivity but had no effect on the changes in norepinephrine serotonin and histamine responses compared to controls. Hypercholesterolemia interfered with relaxation induced by acetylcholine bur with L-arginine, normal acetylcholine-induced, endothelium-dependent relaxation returned (54 +/- 10%, compared to 40 +/- 14% in control veins; p > .05). Non-endothelium-dependent relaxation to sodium nitroprusside of precontracted veins was unaffected by the presence of high cholesterol concentrations. This study suggests that L-arginine therapy may ameliorate hypercholesterolemia-induced functional abnormalities in endothelial cells.
引用
收藏
页码:415 / 422
页数:8
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