A bipolar kinesin

被引：303

作者：

Kashina, AS ^{[1
]}

Baskin, RJ ^{[1
]}

Cole, DG ^{[1
]}

Wedaman, KP ^{[1
]}

Saxton, WM ^{[1
]}

Scholey, JM ^{[1
]}

机构：

[1] INDIANA UNIV,DEPT BIOL,BLOOMINGTON,IN 47405

来源：

NATURE | 1996年 / 379卷 / 6562期

关键词：

D O I：

10.1038/379270a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CHROMOSOME Segregation during mitosis depends on the action of the mitotic spindle, a self-organizing, bipolar protein machine which uses microtubules (MTs) and their associated motors(1,2). Members of the BimC subfamily of kinesin-related MT-motor proteins are believed to be essential for the formation and functioning of a normal bipolar spindle(3-14). Here we report that KRP(130), a homotetrameric BimC-related kinesin purified from Drosophila melanogaster embryos(13), has an ultrastructure. It consists of four kinesin-related polypeptides assembled into a bipolar aggregate with motor domains at opposite ends, analogous to a miniature myosin filament(15). Such a bipolar 'minifilament' could crosslink spindle MTs and slide them relative to one another. We do not know of any other MT motors that have a bipolar structure.

引用

页码：270 / 272

页数：3

共 28 条

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