Autologous peripheral blood progenitor cell transplantation for multiple myeloma

被引：12

作者：

Attal, M

Harousseau, JL

机构：

[1] CHU Purpan, Serv Hematol, F-31059 Toulouse, France

[2] CHU Hotel Dieu, Serv Hematol, F-44093 Nantes, France

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 1999年 / 12卷 / 1-2期

关键词：

autologous stem cell transplantation; peripheral blood progenitor cells; multiple myeloma;

D O I：

10.1053/beha.1999.0015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autologous stem cell transplantation (ASCT) is increasingly used in the treatment of cases of multiple myeloma (MM) where there has been no significant improvement in the patient's condition following conventional chemotherapy. Peripheral blood progenitor cells (PBPC) have replaced bone marrow as a source of stem cells and offer easier accessibility and availability, faster haematopoietic recovery and possibly lower tumour contamination. The IFM 90 randomized trial has shown that autologous bone marrow transplantation significantly improves response rate, event-free survival (EFS) and overall survival (OS) in younger patients with MM. For MM, this review discusses the role of ASCT, the use of PBPC for autologous transplantation, and current developments of ASCT.

引用

页码：171 / 191

页数：21

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