Decreased dopamine receptor expression and its second-messenger cAMP in malignant human colon tissue

被引：39

作者：

Basu, S

Dasgupta, PS

机构：

[1] Chittaranjan Natl Canc Inst, Signal Transduct & Biogen Amines Lab, Kolkata 700026, W Bengal, India

[2] Chittaranjan Natl Canc Inst, Dept Med Oncol, Kolkata 700026, W Bengal, India

来源：

DIGESTIVE DISEASES AND SCIENCES | 1999年 / 44卷 / 05期

关键词：

dopamine receptor; cAMP; malignant tumor; human colon;

D O I：

10.1023/A:1026644110737

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

As an important enteric neurotransmitter, the role of dopamine as a mitotic inhibitor as well as a protective factor of epithelial cells of stomach and colon indicates its significance in malignant growth of gastrointestinal tract. Our previous results have shown significant alteration of dopamine receptors in human malignant stomach tissues. The present experiments, therefore, evaluate DA content, its receptor expression, and its second-messenger cAMP in human malignant colon tissues to evaluate its role. Results demonstrate a significant decrease of dopamine content, its receptor expression, and its second-messenger cAMP in malignant tissues of human colon. These results may provide insight into the role of dopamine as an enteric neurotransmitter on malignant growth of human colon and may also suggest a therapeutic approach targeting dopamine receptors and its signal transduction.

引用

页码：916 / 921

页数：6

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