Wls Is Expressed in the Epidermis and Regulates Embryonic Hair Follicle Induction in Mice

被引：45

作者：

Huang, Sixia ^{[1
]}

Zhu, Xuming ^{[1
]}

Liu, Yanfang ^{[1
]}

Tao, Yixin ^{[1
]}

Feng, Guoyin ^{[1
]}

He, Lin ^{[1
]}

Guo, Xizhi ^{[1
]}

Ma, Gang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Shanghai 200030, Peoples R China

来源：

PLOS ONE | 2012年 / 7卷 / 09期

关键词：

SONIC HEDGEHOG; WNT LIGANDS; MORPHOGENESIS; SECRETION; WNTLESS; PROTEIN; DIFFERENTIATION; INITIATION; AXIS;

D O I：

10.1371/journal.pone.0045904

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Wnt proteins are secreted molecules that play multiple roles during hair follicle development and postnatal hair cycling. Wntless (Wls) is a cargo protein required for the secretion of various Wnt ligands. However, its role during hair follicle development and hair cycling remains unclear. Here, we examined the expression of Wls during hair follicle induction and postnatal hair cycling. We also conditionally deleted Wls with K14-cre to investigate its role in hair follicle induction. K14-cre;Wls(c/c) mice exhibited abnormal hair follicle development, which is possibly caused by impaired canonical Wnt signaling. Meanwhile, Wnt5a is also expressed in embryonic epidermis, but Wnt5a null mice showed no significant defect in embryonic hair follicle morphogenesis. Therefore, Wls may regulate hair follicle induction by mediating the Wnt/beta-catenin pathway.

引用

页数：7

共 24 条

[1]

WNT signals are required for the initiation of hair follicle development [J].