Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri Cusson)

被引：31

作者：

Matsuda, H

Ido, Y

Hirata, A

Ino, Y

Naruto, S

Amamiya, T

Kubo, M

机构：

[1] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan

[2] Daiichi Pharmaceut Co Ltd, Chuo Ku, Tokyo 1038234, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 02期

关键词：

Cnidium monnieri; antipruritic elrect; isopimpinellin; osthol;

D O I：

10.1248/bpb.25.260

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Antipruritic effects of 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri CUSSON, Umberifferae) were investigated. In mice, an oral administration of CM-ext (200 and 500 mg/kg) inhibited compound 48/80-induced scratching behavior without influence on spontaneous locomotion. Isopimpinellin (3) and osthol (1), coumarin derivatives isolated from CM-ext, showed an inhibitory effect on compound 48/80-induced scratching behavior.

引用

收藏

页码：260 / 263

页数：4

相关论文

共 18 条

[1] Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice [J].

Basnet, P ;

Yasuda, I ;

Kumagai, N ;

Tohda, C ;

Nojima, H ;

Kuraishi, Y ;

Komatsu, K .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2001, 24 (09) :1012-1015

[2]

BRAY RE, 1961, P SOC EXP BIOL MED, V106, P255

[3] UPTAKE STORAGE AND RELEASE OF HISTAMINE BY RAT PERITONEAL MAST CELLS IN VITRO [J].

CABUT, M ;

HAEGERMA.O .

ACTA PHYSIOLOGICA SCANDINAVICA, 1966, 68 (02) :206-&

[4] C-13 NUCLEAR MAGNETIC-RESONANCE SPECTRA .11. C-13 NMR CHEMICAL-SHIFTS AND CARBON-PROTON COUPLING-CONSTANTS OF SOME FUROCOUMARINS AND FUROCHROMONES [J].

ELGAMAL, MHA ;

ELEWA, NH ;

ELKHRISY, EAM ;

DUDDECK, H .

PHYTOCHEMISTRY, 1979, 18 (01) :139-143

[5] COUMARINS FROM CHINESE CRUDE DRUG SHEHUANGZI, FRUITS OF CNIDIUM SP AND FROM CNIDIUM-JAPONICUM MIQ [J].

HATA, K ;

BABA, K ;

KOZAWA, M .

YAKUGAKU ZASSHI, 1972, 92 (10) :1289-&

[6]

HONDA G, 1984, Shoyakugaku Zasshi, V38, P221

[7] Studies on Kochiae Fructus .1. Antipruritogenic effect of 70% ethanol extract from Kochiae Fructus and its active component [J].

Kubo, M ;

Matsuda, H ;

Dai, Y ;

Ido, Y ;

Yoshikawa, M .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1997, 117 (04) :193-201

[8] SCRATCHING BEHAVIOR INDUCED BY PRURITOGENIC BUT NOT ALGESIOGENIC AGENTS IN MICE [J].

KURAISHI, Y ;

NAGASAWA, T ;

HAYASHI, K ;

SATOH, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 275 (03) :229-233

[9] RELEASE OF 5-HYDROXYTRYPTAMINE AND HISTAMINE FROM RAT MAST CELLS [J].

MORAN, NC ;

UVNAS, B ;

WESTERHOLM, B .

ACTA PHYSIOLOGICA SCANDINAVICA, 1962, 56 (01) :26-&

[10] CLAISEN REARRANGEMENTS .3. CONVENIENT SYNTHESES OF COUMARINS, OSTHENOL, DEMETHYLSUBEROSIN AND COUMURRAYIN [J].

MURRAY, RDH ;

BALLANTY.MM ;

MATHAI, KP .

TETRAHEDRON, 1971, 27 (06) :1247-&