Antibody-based approaches to diagnosis and characterization of oxidative phosphorylation diseases

被引：5

作者：

Hanson, BJ

Marusich, MF

Capaldi, RA ^{[1
]}

机构：

[1] Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA

[2] Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA

来源：

MITOCHONDRION | 2001年 / 1卷 / 03期

关键词：

mitochondria; oxidative phosphorylation; monoclonal antibody;

D O I：

10.1016/S1567-7249(01)00026-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial disorders caused by defects in oxidative phosphorylation function are difficult to diagnoze. Here we review the emerging use of antibody-based approaches for this diagnosis. Novel methods involving immunohistochemistry and immunocapture of defective enzymes for characterization are described that add to the arsenal of approaches available. (C) 2001 Elsevier Science B.V. and Mitochondria Research Society. All rights reserved.

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收藏

页码：237 / 248

页数：12

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