In vivo Photoacoustic Molecular Imaging with Simultaneous Multiple Selective Targeting Using Antibody-Conjugated Gold Nanorods

被引：206

作者：

Li, Pai-Chi ^{[1
,2
]}

Wang, Churng-Ren Chris ^{[3
]}

Shieh, Dar-Bin ^{[5
]}

Wei, Chen-Wei ^{[2
]}

Liao, Chao-Kang ^{[2
]}

Poe, Carolina ^{[3
]}

Jhan, Suwen ^{[3
]}

Ding, Ann-Ann ^{[4
]}

Wu, Ya-Na ^{[4
]}

机构：

[1] Natl Taiwan Univ, Grad Inst Biomed Elect & Bioinformat, Taipei 106, Taiwan

[2] Natl Taiwan Univ, Dept Elect Engn, Taipei 106, Taiwan

[3] Natl Chung Cheng Univ, Dept Chem & Biochem, Chiayi 621, Taiwan

[4] Natl Cheng Kung Univ, Inst Mol Med, Tainan 701, Taiwan

[5] Natl Cheng Kung Univ, Inst Oral Med, Tainan 701, Taiwan

来源：

OPTICS EXPRESS | 2008年 / 16卷 / 23期

关键词：

D O I：

10.1364/OE.16.018605

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The use of gold nanorods for photoacoustic molecular imaging with simultaneous multiple targeting is reported. Multiple targeting is done by utilizing the tunable optical absorption property of gold nanorods. This technique allows multiple molecular signatures to be obtained by simply switching laser wavelength. HER2 and EGFR were chosen as the primary target molecules for examining two cancer cells, OECM1 and Cal27. Both in vitro and in vivo mouse model imaging experiments were performed, with contrast enhancement of up to 10dB and 3.5dB, respectively. The potential in improving cancer diagnosis is demonstrated. (c) 2008 Optical Society of America

引用

页码：18605 / 18615

页数：11

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