The dangers of inferring treatment effects from observational data: a case study in HIV infection

被引：18

作者：

Dunn, D ^{[1
]}

Babiker, A ^{[1
]}

Hooker, M ^{[1
]}

Darbyshire, J ^{[1
]}

机构：

[1] MRC, Clin Trials Unit, London NW1 2DA, England

来源：

CONTROLLED CLINICAL TRIALS | 2002年 / 23卷 / 02期

关键词：

HIV; observational studies; randomized controlled trials; selection bias; delta trial;

D O I：

10.1016/S0197-2456(01)00200-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Several recent articles have implicitly questioned the need for randomized controlled trials, based on a comparison of treatment effects from observational studies and related randomized controlled trials. We present here a counterexample of a comparison of two antiretroviral drugs used in the treatment of HIV infection, in which the observational analysis gave a potentially misleading result. Examples such as this emphasize the need to regard randomized controlled trials as the primary mechanism for assessing therapeutic efficacy. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：106 / 110

页数：5

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