Total and high-molecular weight adiponectin and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study

被引：62

作者：

Aleksandrova, Krasimira ^{[1
]}

Boeing, Heiner ^{[1
]}

Jenab, Mazda ^{[2
]}

Bueno-de-Mesquita, H. Bas ^{[3
,4
]}

Jansen, Eugene ^{[4
]}

van Duijnhoven, Franzel J. B. ^{[4
,5
]}

Fedirko, Veronika ^{[2
]}

Rinaldi, Sabina ^{[2
]}

Romieu, Isabelle ^{[2
]}

Riboli, Elio ^{[6
]}

Romaguera, Dora ^{[6
]}

Westphal, Sabine ^{[7
]}

Overvad, Kim ^{[8
]}

Tjonneland, Anne ^{[9
,10
]}

Boutron-Ruault, Marie Christine ^{[11
,12
]}

Clavel-Chapelon, Francoise ^{[11
,12
]}

Kaaks, Rudolf ^{[13
]}

Lukanova, Annekatrin ^{[13
]}

Trichopoulou, Antonia ^{[14
,15
]}

Lagiou, Pagona ^{[14
,16
,17
]}

Trichopoulos, Dimitrios ^{[16
,17
]}

Agnoli, Claudia ^{[18
]}

Mattiello, Amalia ^{[19
]}

Saieva, Calogero ^{[20
]}

Vineis, Paolo ^{[6
,21
]}

Tumino, Rosario ^{[22
]}

Peeters, Petra H. ^{[6
,23
]}

Argueelles, Marcial ^{[24
]}

Bonet, Catalina ^{[25
]}

Sanchez, Maria-Jose ^{[26
,27
]}

Dorronsoro, Miren ^{[28
,29
]}

Huerta, Jose-Maria ^{[30
,31
]}

Barricarte, Aurelio ^{[32
,33
]}

Palmqvist, Richard ^{[34
]}

Hallmans, Goran ^{[35
]}

Khaw, Kay-Tee ^{[36
,37
]}

Wareham, Nick ^{[36
,37
]}

Allen, Naomi E. ^{[38
]}

Crowe, Francesca L. ^{[38
]}

Pischon, Tobias ^{[1
,39
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, D-14558 Nuthetal, Germany

[2] Int Agcy Res Canc, Sect Nutr & Metab, F-69372 Lyon, France

[3] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[4] Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr & Hlth, Bilthoven, Netherlands

[5] Wageningen Univ, Div Human Nutr, Wageningen, Netherlands

[6] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Fac Med, Dept Epidemiol & Biostat, London, England

[7] Otto Von Guericke Univ, Fac Med, Inst Clin Chem, Magdeburg, Germany

[8] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[9] Univ Copenhagen, Fac Hlth Sci, Dept Publ Hlth, Copenhagen, Denmark

[10] Inst Canc Epidemiol, Danish Canc Soc, Dept Diet Canc & Hlth, Copenhagen, Denmark

[11] Inst Gustave Roussy, Unit 1018, INSERM, Ctr Res Epidemiol & Populat Hlth,Team 09, F-94805 Villejuif, France

[12] Paris S Univ, UMRS 1018, F-94805 Villejuif, France

[13] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[14] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[15] Hellen Hlth Fdn, Athens, Greece

[16] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[17] Acad Athens, Bur Epidemiol Res, Athens, Greece

[18] Ist Nazl Tumori, Fdn Ist Ricovero & Cura Carattere Sci, Nutr Epidemiol Unit, I-20133 Milan, Italy

[19] Univ Naples Federico II, Fac Med & Surg, Dept Clin & Expt Med, Naples, Italy

[20] ISPO, Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, I-50141 Florence, Italy

[21] Human Genet Fdn HuGeF, Turin, Italy

[22] Civile MP Arezzo Hosp, Dept Oncol, Canc Registry & Histopathol Unit, ASP Ragusa 7, Ragusa, Italy

[23] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[24] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[25] LHosp Llobregat, Catalan Inst Oncol ICO, Unit Nutr Environm & Canc, Barcelona, Spain

[26] CIBERESP, Granada, Spain

[27] Andalusian Sch Publ Hlth, Granada Canc Registry, Granada, Spain

[28] Ctr Invest Biomed Red Epidemiol & Salud Publ, San Sebastian, Spain

[29] Basque Govt, Publ Hlth Div Gipuzkoa, Dept Epidemiol & Hlth Informat, San Sebastian, Spain

[30] CIBERESP, Murcia, Spain

[31] Murcia Reg Hlth Authority, Dept Epidemiol, Murcia, Spain

[32] Publ Hlth Inst Navarra, Serv Epidemiol Prevent & Hlth Promot, Pamplona, Spain

[33] CIBERESP, Consortium Biomed Res Epidemiol & Publ Hlth, Pamplona, Spain

[34] Umea Univ, Fac Med, Dept Med Biosci, Unit Pathol, Umea, Sweden

[35] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[36] Canc Res UK, Cambridge, England

[37] Med Res Council UK, Epidemiol Unit, Cambridge, England

[38] Univ Oxford, Div Med Sci, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[39] Max Delbruck Ctr Mol Med MDC, Mol Epidemiol Grp, Berlin, Germany

来源：

CARCINOGENESIS | 2012年 / 33卷 / 06期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

CORONARY-HEART-DISEASE; ADIPOSE-TISSUE; RECTAL-CANCER; COLON-CANCER; PLASMA; WOMEN; MECHANISMS; OBESITY; GENES; MEN;

D O I：

10.1093/carcin/bgs133

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adiponectin an adipose tissue-derived protein may provide a molecular link between obesity and colorectal cancer (CRC), but evidence from large prospective studies is limited. In particular, no epidemiological study explored high-molecular weight (HMW) and non-HMW adiponectin fractions in relation to CRC risk, despite them being hypothesized to have differential biological activities, i.e. regulating insulin sensitivity (HMW adiponectin) versus inflammatory response (non-HNW adiponectin). In a prospective, nested case control study, we investigated whether prediagnostic serum concentrations of total, HMW and non-HMW adiponectin are associated with risk of CRC, independent of obesity and other known CRC risk factors. A total of 1206 incident cases (755 colon and 451 rectal) were matched to 1206 controls using incidence-density sampling. In conditional logistic regression, adjusted for dietary and lifestyle factors, total adiponectin and non-HMW adiponectin concentrations were inversely associated with risk of CRC [relative risk (RR) comparing highest versus lowest quintile = 0.71, 95% confidence interval (CI) = 0.53-0.95, P-trend = 0.03 for total adiponectin and RR = 0.45, 95% Cl = 0.34-0.61, P-trend < 0.0001 for non-HMW adiponectin] HMW adiponectin concentrations were not associated with CRC risk (RR = 0.91, 95% Cl = 0.68-1.22, P-trend = 0.55). Non-HMW adiponectin was associated with CRC risk even after adjustment for body mass index and waist circumference (RR = 0.39, 95% CI = 0.26-0.60, P-trend < 0.0001), whereas the association with total adiponectin was no longer significant (RR = 0.81, 95% CI = 0.60A.09, P-trend = 0.23). When stratified by cancer site, non-HMW adiponectin was inversely associated with both colon and rectal cancer. These findings suggest an important role of the relative proportion of non-HMW adiponectin in CRC pathogenesis. Future studies are warranted to confirm these results and to elucidate the underlying mechanisms.

引用

页码：1211 / 1218

页数：8

共 42 条

[1] Adipose tissue as an endocrine organ [J].

Ahima, Rexford S. .

OBESITY, 2006, 14 :242-249

[2] The metabolic syndrome - a new worldwide definition [J].

Alberti, KGMM ;

Zimmet, P ;

Shaw, J .

LANCET, 2005, 366 (9491) :1059-1062

[3] Circulating C-Reactive Protein Concentrations and Risks of Colon and Rectal Cancer: A Nested Case-Control Study Within the European Prospective Investigation into Cancer and Nutrition [J].

Aleksandrova, Krasimira ;

Jenab, Mazda ;

Boeing, Heiner ;

Jansen, Eugene ;

Bueno-de-Mesquita, H. Bas ;

Rinaldi, Sabina ;

Riboli, Elio ;

Overvad, Kim ;

Dahm, Christina C. ;

Olsen, Anja ;

Tjonneland, Anne ;

Boutron-Ruault, Marie-Christine ;

Clavel-Chapelon, Francoise ;

Morois, Sophie ;

Palli, Domenico ;

Krogh, Vittorio ;

Tumino, Rosario ;

Vineis, Paolo ;

Panico, Salvatore ;

Kaaks, Rudolf ;

Rohrmann, Sabine ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

van Duijnhoven, Fraenzel J. B. ;

Leufkens, Anke M. ;

Peeters, Petra H. ;

Rodriguez, Laudina ;

Bonet, Catalina ;

Sanchez, Maria-Jose ;

Dorronsoro, Miren ;

Navarro, Carmen ;

Barricarte, Aurelio ;

Palmqvist, Richard ;

Hallmans, Goran ;

Khaw, Kay-Tee ;

Wareham, Nicholas ;

Allen, Naomi E. ;

Spencer, Elizabeth ;

Romaguera, Dora ;

Norat, Teresa ;

Pischon, Tobias .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2010, 172 (04) :407-418

[4] Adiponectin levels in patients with colorectal cancer and adenoma: a meta-analysis [J].

An, Wei ;

Bai, Yu ;

Deng, Shang-Xin ;

Gao, Jie ;

Ben, Qi-Wen ;

Cai, Quan-Cai ;

Zhang, Hua-Gao ;

Li, Zhao-Shen .

EUROPEAN JOURNAL OF CANCER PREVENTION, 2012, 21 (02) :126-133

[5] Adiponectin in relation to malignancies: a review of existing basic research and clinical evidenced [J].

Barb, Diana ;

Williams, Catherine J. ;

Neuwirth, Anke K. ;

Mantzoros, Christos S. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 86 (03) :858S-866S

[6] Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program -: Comparative evaluation of three assays [J].

Blueher, Matthias ;

Fasshauer, Mathias ;

Brennan, Aoife M. ;

Kralisch, Susan ;

Kelesidis, Theodoros ;

Williams, Catherine J. ;

Kratzsch, Juergen ;

Mantzoros, Christos S. .

DIABETES CARE, 2007, 30 (02) :280-285

[7] Adiponectin action from head to toe [J].

Brochu-Gaudreau, Karine ;

Rehfeldt, Charlotte ;

Blouin, Richard ;

Bordignon, V. ;

Murphy, Bruce D. ;

Palin, Marie-France .

ENDOCRINE, 2010, 37 (01) :11-32

[8] Adiponectin and adiponectin receptor in relation to colorectal cancer progression [J].

Byeon, Jeong-Sik ;

Jeong, Jin-Yong ;

Kim, Mi Jung ;

Lee, Sun-Mi ;

Nam, Won-Hee ;

Myung, Seung-Jae ;

Kim, Jae Gyu ;

Yang, Suk-Kyun ;

Kim, Jin-Ho ;

Suh, Dong Jin .

INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (12) :2758-2767

[9] Adiponectin: More than just another fat cell hormone? [J].

Chandran, M ;

Phillips, SA ;

Ciaraldi, T ;

Henry, RR .

DIABETES CARE, 2003, 26 (08) :2442-2450

[10] Metabolic syndrome, hyperinsulinemia, and colon cancer: a review [J].

Giovannucci, Edward .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 86 (03) :836S-842S

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