Tumor suppressors: Control of signaling by endocytosis

被引：31

作者：

Giebel, B

Wodarz, A

机构：

[1] Univ Dusseldorf, Inst Transplantat Diagnost & Cell Therapeut, D-40225 Dusseldorf, Germany

[2] Univ Gottingen, Dept Stem Cell Biol, CMPB, D-37077 Gottingen, Germany

来源：

CURRENT BIOLOGY | 2006年 / 16卷 / 03期

关键词：

D O I：

10.1016/j.cub.2006.01.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic defects of the endosomal 'ESCRT' machinery in Drosophila have been found to cause loss of epithelial cell polarity, accompanied by overproliferation of mutant and adjacent wild-type cells. These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch.

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收藏

页码：R91 / R92

页数：2

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