Structure-activity relationship of antibacterial chalcones

被引：242

作者：

Avila, Hugo Pereira ^{[1
]}

Albino Smania, Elza de Fatima ^{[1
]}

Delle Monache, Franco ^{[2
]}

Junior, Artur Smania ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Microbiol & Parasitol, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Rome, Dipartimento Chim & Tecnol Sostanze Biol Camente, Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 22期

关键词：

Chalcone; 4-Hydroxy-derricin; Antibacterial activity; Bacteria; Minimal inhibitory concentration; Minimal bactericidal concentration;

D O I：

10.1016/j.bmc.2008.09.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The antibacterial activity of 31 chalcones was tested against bacterial strains, Bacillus cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus ATCC 25923. Some of the tested chalcones showed fair to significant activity against Gram-positive bacteria. By comparison of the results obtained, the antibacterial activity can be related to features such as the presence of a C-4 hydroxyl group, a C-4' oxygenated substituent or a C-3' isoprenoid side chain, while the C-2' hydroxyl group might have importance for the stability of the molecule. The inhibitory effect of chalcones on human pathogenic microorganisms can be correlated with the substitution patterns of the aromatics rings. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：9790 / 9794

页数：5

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