Modifications of the isonipecotic acid fragment of SNS-032: Analogs with improved permeability and lower efflux ratio

被引：7

作者：

Fan, Junfa ^{[1
]}

Fahr, Bruce ^{[1
]}

Stockett, David ^{[1
]}

Chan, Erica ^{[1
]}

Cheeti, Sravanthi ^{[1
]}

Serafimova, Iana ^{[1
]}

Lu, Yafan ^{[1
]}

Pham, Phuongly ^{[1
]}

Walker, Duncan H. ^{[1
]}

Hoch, Ute ^{[1
]}

Choong, Ingrid C. ^{[1
]}

机构：

[1] Sunesis Pharmaceut, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 23期

关键词：

CDK; Cyclin; SNS-032; Kinase;

D O I：

10.1016/j.bmcl.2008.09.099

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Modifications of the isonipecotic acid fragment of SNS-032 results in analogs which are more permeable and lower effluxed than SNS-032. The enantiomerically pure synthesis and the in vivo pro. le of analog 20 is described. (C) 2008 Elsevier Ltd. All rights reserved.

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收藏

页码：6236 / 6239

页数：4

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