Highly sensitive ac nanocalorimeter for microliter-scale liquids or biological samples

被引：43

作者：

Garden, JL ^{[1
]}

Chateau, E ^{[1
]}

Chaussy, J ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS, Lab Associe, CNRS,Ctr Rech Tres Basses Temp, F-38042 Grenoble 9, France

来源：

APPLIED PHYSICS LETTERS | 2004年 / 84卷 / 18期

关键词：

D O I：

10.1063/1.1737794

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We developed an ultrasensitive ac nanocalorimeter for use with biological liquids by means of microfabrication technologies. The volume of the cell measurement is only 5 muL. This nanocalorimeter, tested on deionized water, allows the measurement of heat capacity variation above +/-150 nJ/K (resolution of +/-5x10(-6)) with an operating temperature ranging from -20 to 120 degreesC and a stability of 100 muK. Its use is demonstrated on diluted lysosyme solution measured at the frequency of 3 Hz. At 3 Hz, this ac calorimeter gives only the variation of the heat capacity during the denaturation, which allows complementary thermodynamic investigations as regards to classical differential scanning calorimetry measurements. (C) 2004 American Institute of Physics.

引用

页码：3597 / 3599

页数：3

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