Silica, alumina and clay catalyzed peptide bond formation:: Enhanced efficiency of alumina catalyst

被引：89

作者：

Bujdák, J

Rode, BM

机构：

[1] Slovak Acad Sci, Inst Inorgan Chem, Bratislava 84236, Slovakia

[2] Univ Innsbruck, Inst Gen Inorgan & Theoret Chem, A-6020 Innsbruck, Austria

来源：

ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES | 1999年 / 29卷 / 05期

关键词：

D O I：

10.1023/A:1006524703513

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Catalytic efficiencies of clay (hectorite), silica and alumina were tested in peptide bond formation reactions of glycine (Gly), alanine (Ala), proline (Pro), valine (Val) and leucine (Leu). The reactions were performed as drying/wetting (hectorite) and temperature fluctuation (silica and alumina) experiments at 85 degrees C. The reactivity of amino acids decreased in order Gly > Ala > Pro approximate to Val approximate to Leu. The highest catalytic efficiency was observed for alumina, the only catalyst producing oligopeptides in all investigated reaction systems. The peptide bond formation on alumina is probably catalyzed by the same sites and via similar reaction mechanisms as some alumina-catalyzed dehydration reactions used in industrial chemistry.

引用

页码：451 / 461

页数：11

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