Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

被引：137

作者：

Chang, Chongwang ^{[1
]}

Lang, Hongjuan ^{[2
]}

Geng, Ning ^{[1
]}

Wang, Jing ^{[1
]}

Li, Nan ^{[1
]}

Wang, Xuelian ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Peoples R China

[2] Fourth Mil Med Univ, Tangdu Hosp, Dept Nursing, Xian 710038, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2013年 / 548卷

关键词：

Parkinson's disease; Exosome; Microglia; Alpha-synuclein; PARKINSONS-DISEASE; INFLAMMATION; MICROGLIA; PATHOLOGY; IMMUNITY;

D O I：

10.1016/j.neulet.2013.06.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Parkinson's disease (PD) is a progressive neurodegenerative disease. Alpha-synuclein aggregation, which can activate microglia to enhance its dopaminergic neurotoxicity, plays a central role in the progression of PD. However the mechanism is still unclear. To investigate how alpha-synuclein affects the neuron, exosomes were derived from alpha-synuclein treated mouse microglia cell line BV-2 cells by differential centrifugation and ultracentrifugation. We found that alpha-synuclein can induce an increase of exosomal secretion by microglia. These activated exosomes expressed a high level of MHC class II molecules and membrane TNF-alpha. In addition, the activated exosomes cause increased apoptosis. Exosomes secreted from activated microglias might be important mediator of alpha-synuclein-induced neurodegeneration in PD. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：190 / 195

页数：6

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