Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons

被引：73

作者：

Ugolini, A ^{[1
]}

Corsi, M ^{[1
]}

Bordi, F ^{[1
]}

机构：

[1] GLAXOWELLCOME MED RES CTR,DEPT PHARMACOL,VERONA,ITALY

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 08期

关键词：

ionotropic glutamate receptor agonists; metabotropic glutamate receptor agonists; 1S; 3R-ACPD; DHPG; protein kinase C; 4CPG; MCPG; chelerytrine chloride; plasticity; nociception;

D O I：

10.1016/S0028-3908(97)00103-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Application of the metabotropic glutamate receptor (mGluR) agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) and the Group I selective mGluR agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) potentiated NMDA-and AMPA-induced potential changes recorded from ventral roots of the isolated hemisected baby rat spinal cord. Potentiation produced by 1S,3R-ACPD was completely abolished by the Group I selective mGluR antagonists (S)-4-carboxyphenylglycine (4CPG) or (+)-alpha-methyl-4-carboxyphenylglycine (MCPG). In addition, the protein kinase C (PKC) blockers staurosporine or chelerythrine chloride were able to antagonize the 1S,3R-ACPD-induced potentiation of both NMDA and AMPA response, suggesting that the enhancing effect induced by Group I mGluRs is modulated by a PKC-mediated mechanism. The mGluRs-induced potentiation of NMDA and AMPA responses may be important in modulating various forms of synaptic plasticity and nociceptive processes. (C) 1997 Elsevier Science Ltd.

引用

页码：1047 / 1055

页数：9

共 34 条

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