NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction

被引：107

作者：

Als, H. ^{[1
,2
]}

Duffy, F. H. ^{[2
,3
]}

McAnulty, G. ^{[1
,2
]}

Butler, S. C. ^{[1
,2
]}

Lightbody, L. ^{[1
,2
]}

Kosta, S. ^{[1
,2
]}

Weisenfeld, N. I. ^{[2
,4
]}

Robertson, R. ^{[2
,4
]}

Parad, R. B. ^{[2
,5
]}

Ringer, S. A. ^{[2
,5
]}

Blickman, J. G. ^{[6
]}

Zurakowski, D. ^{[2
,7
]}

Warfield, S. K. ^{[2
,4
]}

机构：

[1] Childrens Hosp, Dept Psychiat, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Childrens Hosp, Dept Neurol, Boston, MA 02115 USA

[4] Childrens Hosp, Dept Radiol, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Div Newborn Med, Boston, MA 02115 USA

[6] Univ Rochester, Med Ctr, Dept Imaging Sci, Rochester, NY 14642 USA

[7] Childrens Hosp, Dept Anesthesia, Boston, MA 02115 USA

来源：

JOURNAL OF PERINATOLOGY | 2012年 / 32卷 / 10期

基金：

美国国家卫生研究院;

关键词：

NIDCAP; intrauterine growth restriction; preterm infants; APIB; EEG; MRI; INDIVIDUALIZED DEVELOPMENTAL CARE; ASSESSMENT PROGRAM NIDCAP; NEWBORN; PREMATURE; RISK; AGE;

D O I：

10.1038/jp.2011.201

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: The effect of NIDCAP (Newborn Individualized Developmental Care and Assessment Program) was examined on the neurobehavioral, electrophysiological and neurostructural development of preterm infants with severe intrauterine growth restriction (IUGR). Study Design: A total of 30 infants, 27-33 weeks gestation, were randomized to control (C; N = 17) or NIDCAP/experimental (E; N = 13) care. Baseline health and demographics were assessed at intake; electroencephalography (EEG) and magnetic resonance imaging (MRI) at 35 and 42 weeks postmenstrual age; and health, growth and neurobehavior at 42 weeks and 9 months corrected age (9 months). Results: C and E infants were comparable in health and demographics at baseline. At follow-up, E infants were healthier, showed significantly improved brain development and better neurobehavior. Neurobehavior, EEG and MRI discriminated between C and E infants. Neurobehavior at 42 weeks correlated with EEG and MRI at 42 weeks and neurobehavior at 9 months. Conclusion: NIDCAP significantly improved IUGR preterm infants' neurobehavior, electrophysiology and brain structure. Longer-term outcome assessment and larger samples are recommended. Journal of Perinatology (2012) 32, 797-803; doi:10.1038/jp.2011.201; published online 2 February 2012

引用

页码：797 / 803

页数：7

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