Fluorinase mediated C-18F bond formation, an enzymatic tool for PET labelling

被引：62

作者：

Deng, H

Cobb, SL

Gee, AD

Lockhart, A

Martarello, L

McGlinchey, RP

O'Hagan, D

Onega, M

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

[3] Addenbrookes Hosp, GlaxoSmithKline, Cambridge CB2 2GG, England

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b516861a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [F-18]-fluoride into [F-18]-5'-fluoro-5'-deoxyadenosine, [F-18]-5'-fluoro-5'-deoxyinosine and [F-18]-5-fluoro-5-deoxyribose for positron emission tomography (PET) applications.

引用

收藏

页码：652 / 654

页数：3

相关论文

共 14 条

[1] Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents [J].

Alauddin, MM ;

Fissekis, JD ;

Conti, PS .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2003, 46 (09) :805-814

[2] Directed evolution of enzymes: new biocatalysts for asymmetric synthesis [J].

Alexeeva, M ;

Carr, R ;

Turner, NJ .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (23) :4133-4137

[3] Enzymatic fluorination in Streptomyces cattleya takes place with an inversion of configuration consistent with an SN2 reaction mechanism [J].

Cadicamo, CD ;

Courtieu, J ;

Deng, H ;

Meddour, A ;

O'Hagan, D .

CHEMBIOCHEM, 2004, 5 (05) :685-690

[4]

DENG H, IN PRESS ANGEW CHEM

[5] Crystal structure and mechanism of a bacterial fluorinating enzyme [J].

Dong, CJ ;

Huang, FL ;

Deng, H ;

Schaffrath, C ;

Spencer, JB ;

O'Hagan, D ;

Naismith, JH .

NATURE, 2004, 427 (6974) :561-565

[6]

Goodman MM, 1991, CLIN POSITRON EMISSI, P110

[7] THE FLUORINATED NATURAL-PRODUCTS [J].

HARPER, DB ;

OHAGAN, D .

NATURAL PRODUCT REPORTS, 1994, 11 (02) :123-133

[8] The first enzymatic method for C-18F bond formation:: the synthesis of 5′-[18F]-fluoro-5′deoxyadenosine for imaging with PET [J].

Martarello, L ;

Schaffrath, C ;

Deng, H ;

Gee, AD ;

Lockhart, A ;

O'Hagan, D .

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2003, 46 (13) :1181-1189

[9] Biosynthesis of an organofluorine molecule - A fluorinase enzyme has been discovered that catalyses carbon-fluorine bond formation. [J].

O'Hagan, D ;

Schaffrath, C ;

Cobb, SL ;

Hamilton, JTG ;

Murphy, CD .

NATURE, 2002, 416 (6878) :279-279

[10] Assay for the enantiomeric analysis of [2H1]-fluoroacetic acid:: Insight into the stereochemical course of fluorination during fluorometabolite biosynthesis in Streptomyces cattleya [J].

O'Hagan, D ;

Goss, RJM ;

Meddour, A ;

Courtieu, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (02) :379-387