Myocardial protective effect of Sheng Mai San (SMS) and a lignan-enriched extract of Fructus Schisandrae, in vivo and ex vivo

被引：36

作者：

Li, PC ^{[1
]}

Mak, DHF ^{[1
]}

Poon, MKT ^{[1
]}

Ip, SP ^{[1
]}

Ko, KM ^{[1
]}

机构：

[1] HONG KONG UNIV SCI & TECHNOL,DEPT BIOCHEM,HONG KONG,HONG KONG

来源：

PHYTOMEDICINE | 1996年 / 3卷 / 02期

关键词：

Sheng Mai San; Schisandra chinensis; coronary heart disease; antioxidant;

D O I：

10.1016/S0944-7113(96)80039-0

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Effects of Sheng Mai San (SMS), a traditional Chinese medicine used for the treatment of coronary heart disease, and the lignan-enriched extract of Fructus Schisandrae (FS), an antioxidant component of SMS, were examined in an in vivo model of myocardial infarction and an ex vivo model of myocardial ischemia-reperfusion injury in rats. Pretreatment with SMS (12 g/kg/day x 3, p.o.) or FS extract (0.8 g/kg/day x 3, p.o.) was found to protect against the isoproterenol-induced myocardial injury in rats and the ischemia-reperfusion injury in isolated perfused hearts prepared from the pretreated animals. Pretreatment with alpha-tocopherol (0.8 g/kg/day x 3, p.o.) produced similar beneficial effect on the myocardium. The myocardial protection afforded by SMS pretreatment is likely, at least in part, mediated by the FS-derived antioxidant activity.

引用

页码：217 / 221

页数：5

共 17 条

[1]

BOOR PJ, 1979, RES COMMUN CHEM PATH, V24, P27

[2]

CHEN M, 1990, ACTA PHARM SINIC, V11, P161

[3]

Chen S., 1993, CLIN GUIDE CHINESE H, P75

[4] FUNCTIONAL AND SUBCELLULAR CHANGES IN ISOLATED RAT-HEART PERFUSED WITH OXIDIZED ISOPROTERENOL [J].

DHALLA, NS ;

YATES, JC ;

LEE, SL ;

SINGH, A .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1978, 10 (01) :31-+

[5] OXYGEN-MEDIATED MYOCARDIAL DAMAGE DURING ISCHEMIA AND REPERFUSION - ROLE OF THE CELLULAR DEFENSES AGAINST OXYGEN-TOXICITY [J].

FERRARI, R ;

CECONI, C ;

CURELLO, S ;

GUARNIERI, C ;

CALDARERA, CM ;

ALBERTINI, A ;

VISIOLI, O .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1985, 17 (10) :937-945

[6] Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats [J].

Ip, SP ;

Mak, DHF ;

Li, PC ;

Poon, MKT ;

Ko, KM .

PHARMACOLOGY & TOXICOLOGY, 1996, 78 (06) :413-416

[7]

Ko K. M., 1993, Fitoterapia, V64, P539

[8] EFFECT OF A LIGNAN-ENRICHED FRUCTUS-SCHISANDRAE EXTRACT ON HEPATIC GLUTATHIONE STATUS IN RATS - PROTECTION AGAINST CARBON-TETRACHLORIDE TOXICITY [J].

KO, KM ;

IP, SP ;

POON, MKT ;

WU, SS ;

CHE, CT ;

NG, KH ;

KONG, YC .

PLANTA MEDICA, 1995, 61 (02) :134-137

[9] SCHISANDRA-CHINENSIS-DERIVED ANTIOXIDANT ACTIVITIES IN SHENG-MAI SAN A COMPOUND FORMULATION, IN-VIVO AND IN-VITRO [J].

KO, KM ;

YICK, PK ;

POON, MKT ;

CHE, CT ;

NG, KH ;

KONG, YC .

PHYTOTHERAPY RESEARCH, 1995, 9 (03) :203-206

[10]

LIN TJ, 1991, BIOCHEM PHARMACOL, V42, P1805

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