Chiral 2,2′-bipyridine-type N-monoxides as organocatalysts in the enantioselective allylation of aldehydes with allyltrichlorosilane

被引:178
作者
Malkov, AV
Orsini, M
Pernazza, D
Muir, KW
Langer, V
Meghani, P
Kocovsky, P [1 ]
机构
[1] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland
[2] Chalmers Univ Technol, Dept Inorgan Environm Chem, S-41296 Gothenburg, Sweden
[3] AstraZeneca R&D, Loughborough LE11 5RH, Leics, England
关键词
D O I
10.1021/ol025654m
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] The Sakurai-Hosomi-type allylation of aromatic and heteroaromatic aldehydes can be catalyzed by the new heterobidenate bipyridine monoxide PINDOX with high enantioselectivities. The sterochemical outcome is mainly controlled by the axial chirality in PINDOX, which in turn is determined by the annulated terpene units.
引用
收藏
页码:1047 / 1049
页数:3
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