Genomic diversity in the Leishmania donovani complex

被引：132

作者：

Mauricio, IL ^{[1
]}

Howard, MK ^{[1
]}

Stothard, JR ^{[1
]}

Miles, MA ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, Pathogen Mol Biol & Biochem Unit, London WC1E 7HT, England

来源：

PARASITOLOGY | 1999年 / 119卷

基金：

英国惠康基金;

关键词：

Leishmania donovani complex; Leishmania infantum; Leishmania chagasi; visceral leishmaniasis; RAPD analysis;

D O I：

10.1017/S0031182099004710

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The Leishmania donovani complex is considered to be composed of 3 species; L. donovani, L, infantum and L. chagasi, although this classification has been challenged. Genotypic relationships within the complex were evaluated at different levels by: binding of the probe Lmet9, specific for L. chagasi and Old World Leishmania spp.; partial sequencing of a constitutive major surface protease single gene (mspC) and random amplification of polymorphic DNA (RAPD). The Old World Leishmania spp, and the L. donovani complex have a monophyletic origin. Leishmania chagasi clearly belongs to the L, donovani complex but it is indistinguishable from L. infantum, which suggests introduction of L. chagasi into the New World in recent history. Leishmania infantum/L. chagasi was identified as a monophyletic group within the L. donovani complex but L. donovani may be paraphyletic. Diversity within L. donovani is substantial and phylogeographical patterns of association were found.

引用

页码：237 / 246

页数：10

共 40 条

[1] Random amplified polymorphic DNA for the differentiation of Leishmania donovani isolates from Sudan [J].