Cytokines and Perinatal Brain Damage

被引：149

作者：

Dammann, Olaf ^{[2
]}

O'Shea, T. Michael ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Winston Salem, NC 27157 USA

[2] Floating Hosp Children, Tufts Med Ctr, Div Newborn Med, Boston, MA 02111 USA

来源：

CLINICS IN PERINATOLOGY | 2008年 / 35卷 / 04期

关键词：

Cytokines; Developmental disability; Cerebral palsy; Mental retardation; Periventricular leukomalacia; Chorioamnionitis;

D O I：

10.1016/j.clp.2008.07.011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Perinatal brain damage has been implicated in the pathogenesis of neuro-developmental impairments and psychiatric illnesses. This article reviews evidence that infection outside of the brain can damage the brain, and discusses specific cytokines and pathomechanisms that probably mediate the putative effect of remote infection on the developing brain. Events associated with increased circulating inflammatory cytokines, chemokines, and immune cells are described. Finally, studies of genetic variation in susceptibility to cytokine-related brain damage are reviewed.

引用

页码：643 / 663

页数：21

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