Levels of appraisal: A medial prefrontal role in high-level appraisal of emotional material

被引:150
作者
Kalisch, Raffael [1 ]
Wiech, Katja [1 ]
Critchley, Hugo D. [1 ]
Dolan, Raymond J. [1 ]
机构
[1] UCL, Inst Neurol, Funct Imaging Lab, Wellcome Dept Imaging Neurosci, London WC1N 3BG, England
基金
英国惠康基金;
关键词
D O I
10.1016/j.neuroimage.2005.11.011
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Appraisal refers to the evaluation of the meaning of emotional stimuli and is considered causal in the generation of an emotional response. Cognitive neuroscience has paid little attention to a theoretical distinction between low-level appraisal, considered to be automatic and preattentive, and high-level appraisal that requires attentional and working memory resources. To disentangle low-level from high-level appraisal, we varied cognitive load in a concurrent, unrelated working memory task, while anxiety was induced through anticipation of impending pain. Confirming theoretical predictions, we show that anxiety-related activity in dorsal medial prefrontal/rostral anterior cingulate cortex (dorsal MPFC/ACC) is attenuated under high, relative to low, cognitive load. Lateral prefrontal regions previously implicated in reappraisal and cognitive emotion regulation show a similar interaction between anxiety and cognitive load. Critically, there were no changes in physiological and subjective measures of low-level appraisal outcome and emotional response generation as a function of load, allowing us to conclude that MPFC/ACC and lateral PFC activity during anticipatory anxiety reflects high-level appraisal. Our data provide neurobiological evidence for a distinction between low-level and high-level appraisal mechanisms. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:1458 / 1466
页数:9
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