TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases

被引：17

作者：

Bernardi, Stella ^{[1
,2
]}

Milani, Daniela ^{[1
]}

Fabris, Bruno ^{[2
]}

Secchiero, Paola ^{[1
]}

Zauli, Giorgio ^{[3
]}

机构：

[1] Univ Ferrara, Dept Morphol & Embriol, I-44100 Ferrara, Italy

[2] Univ Trieste, Osped Cattinara, Dept Med Surg & Hlth Sci, I-34149 Trieste, Italy

[3] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34100 Trieste, Italy

来源：

CURRENT DRUG TARGETS | 2012年 / 13卷 / 09期

关键词：

Cardiovascular diseases; diabetes; TRAIL; APOPTOSIS-INDUCING LIGAND; NF-KAPPA-B; SMOOTH-MUSCLE-CELLS; C-REACTIVE PROTEIN; ENDOTHELIAL-CELLS; T-CELLS; OSTEOPROTEGERIN LEVELS; CANCER-CELLS; RISK-FACTORS; SERUM-LEVELS;

D O I：

10.2174/138945012802002357

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of TRAIL on cardiovascular diseases and diabetes.

引用

收藏

页码：1215 / 1221

页数：7

相关论文

共 63 条

[1]

Safety and antitumor activity of recombinant soluble Apo2 ligand [J].

Ashkenazi, A ;

Pai, RC ;

Fong, S ;

Leung, S ;

Lawrence, DA ;

Masters, SA ;

Blackie, C ;

Chang, L ;

McMurtrey, AE ;

Hebert, A ;

DeForge, L ;

Koumenis, IL ;

Lewis, D ;

Harris, L ;

Bussiere, J ;

Koeppen, H ;

Shahrokh, Z ;

Schwall, RH .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) :155-162

[2]

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists [J].

Ashkenazi, Avi .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (12) :1001-1012

[3]

C-reactive protein and other inflammatory risk markers in acute coronary syndromes [J].

Blake, GJ ;

Ridker, PM .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (04) :37S-42S

[4]

Biomarkers in heart failure [J].

Braunwald, Eugene .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (20) :2148-2159

[5]

Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes [J].

Campioni, D ;

Secchiero, P ;

Corallini, F ;

Melloni, E ;

Capitani, S ;

Lanza, F ;

Zauli, G .

AMERICAN JOURNAL OF PATHOLOGY, 2005, 166 (02) :557-563

[6]

TRAIL Promotes VSMC Proliferation and Neointima Formation in a FGF-2-, Sp1 Phosphorylation-, and NFκB-Dependent Manner [J].

Chan, Jeffrey ;

Prado-Lourenco, Leonel ;

Khachigian, Levon M. ;

Bennett, Martin R. ;

Di Bartolo, Belinda A. ;

Kavurma, Mary M. .

CIRCULATION RESEARCH, 2010, 106 (06) :1061-1071

[7]

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice [J].

Cretney, E ;

Takeda, K ;

Yagita, H ;

Glaccum, M ;

Peschon, JJ ;

Smyth, MJ .

JOURNAL OF IMMUNOLOGY, 2002, 168 (03) :1356-1361

[8]

TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe-/- mice [J].

Di Bartolo, B. A. ;

Chan, J. ;

Bennett, M. R. ;

Cartland, S. ;

Bao, S. ;

Tuch, B. E. ;

Kavurma, M. M. .

DIABETOLOGIA, 2011, 54 (12) :3157-3167

[9]

Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L [J].

Di Pietro, R ;

Zauli, G .

JOURNAL OF CELLULAR PHYSIOLOGY, 2004, 201 (03) :331-340

[10]

TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-κB [J].

Ehrhardt, H ;

Fulda, S ;

Schmid, I ;

Hiscott, J ;

Debatin, KM ;

Jeremias, I .

ONCOGENE, 2003, 22 (25) :3842-3852

← 1 2 3 4 5 6 7 →