Catechol as a nucleophilic catalyst of peptide bond formation

被引：16

作者：

Ivanova, G ^{[1
]}

Bratovanova, E ^{[1
]}

Petkov, D ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Organ Chem, Lab BioCatalysis, BU-1113 Sofia, Bulgaria

来源：

JOURNAL OF PEPTIDE SCIENCE | 2002年 / 8卷 / 01期

关键词：

catalysis; enzyme mimetics; neighbouring group effect; peptides; ribozymes;

D O I：

10.1002/psc.362

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aminolysis of a mildly activated aminoacid ester, benzyloxycarbonyl-(L)-phenylalanine cyanomethyl ester. by glycine esters in the presence of catechol has been studied as it model of catalysis by RNA cis-vicinal-diol systems in protein biosynthesis. Catechol accelerated the aminolysis, especially in the presence of bases, probably by nucleophilic catalysis. Copyright (C) 2002 European Peptide Society and John Wiley Sons, Ltd.

引用

页码：8 / 12

页数：5

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