Putative mechanisms of the relationship between obesity and migraine progression

被引：30

作者：

Bigal, Marcelo E. ^{[1
]}

Lipton, Richard B. ^{[1
]}

机构：

[1] Merck Res Labs, White House Stn, NJ 08889 USA

来源：

CURRENT PAIN AND HEADACHE REPORTS | 2008年 / 12卷 / 03期

关键词：

D O I：

10.1007/s11916-008-0036-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Studies suggest that obesity is associated with migraine progression from an episodic into a chronic form. We discuss putative mechanisms to justify this relationship. Several of the inflammatory mediators that are increased in obese individuals are important in migraine pathophysiology, including interleukins and calcitonin gene-related peptide. Both migraine and obesity are prothrombotic states. Substances that are important in metabolic control are nociceptive at certain levels. Hypothalamic dysfunction in the orexin pathways seems to be a risk factor for both conditions. In addition, we discuss the importance of metabolic syndrome and autonomic dysfunction in modulating the obesity/migraine progression relationship.

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页码：207 / 212

页数：6

相关论文

共 48 条

[1]

BARANOWSKA B, 2005, NEURO ENDOCRINOL LET, V26, P714

[2] Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area [J].

Bartsch, T ;

Levy, MJ ;

Knight, YE ;

Goadsby, PJ .

PAIN, 2004, 109 (03) :367-378

[3] Body mass index and episodic headaches - A population-based study [J].

Bigal, Marcelo E. ;

Tsang, Amy ;

Loder, Elizabeth ;

Serrano, Daniel ;

Reed, Michael L. ;

Lipton, Richard B. .

ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (18) :1964-1970

[4] Obesity, migraine, and chronic migraine - Possible mechanisms of interaction [J].

Bigal, Marcelo E. ;

Lipton, Richard B. ;

Holland, Philip R. ;

Goadsby, Peter J. .

NEUROLOGY, 2007, 68 (21) :1851-1861

[5] Obesity is a risk factor for transformed migraine but not chronic tension-type headache [J].

Bigal, Marcelo E. ;

Lipton, Richard B. .

NEUROLOGY, 2006, 67 (02) :252-257

[6] Obesity and migraine - A population study [J].

Bigal, ME ;

Liberman, JN ;

Lipton, RB .

NEUROLOGY, 2006, 66 (04) :545-550

[7] Comorbidity of migraine and depression - Investigating potential etiology and prognosis [J].

Breslau, N ;

Lipton, RB ;

Stewart, WF ;

Schultz, LR ;

Welch, KMA .

NEUROLOGY, 2003, 60 (08) :1308-1312

[8] Prospective investigation of autonomic nervous system function and the development of type 2 diabetes - The Atherosclerosis Risk in Communities study, 1987-1998 [J].

Carnethon, MR ;

Golden, SH ;

Folsom, AR ;

Haskell, W ;

Liao, DP .

CIRCULATION, 2003, 107 (17) :2190-2195

[9] The emerging anti-inflammatory role of HDL-cholesterol, illustrated in cardiovascular disease free population; the ATTICA study [J].

Chrysohoou, Christina ;

Pitsavos, Christos ;

Skoumas, John ;

Masoura, Constantina ;

Katinioti, Anastasia ;

Panagiotakos, Demosthenes ;

Stefanadis, Christodoulos .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2007, 122 (01) :29-33

[10] Macrophages in human visceral adipose tissue:: increased accumulation in obesity and a source of resistin and visfatin [J].

Curat, CA ;

Wegner, V ;

Sengenès, C ;

Miranville, A ;

Tonus, C ;

Busse, R ;

Bouloumié, A .

DIABETOLOGIA, 2006, 49 (04) :744-747

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