DNA repair - Tails of histones lost

被引:15
作者
Nussenzweig, A
Paull, T
机构
[1] NIH, Expt Immunol Branch, Bethesda, MD 20892 USA
[2] Univ Texas, Dept Mol Genet & Microbiol, Austin, TX 78712 USA
关键词
D O I
10.1038/439406a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A double-stranded break in DNA can profoundly destabilize a cell's genome. But how does the cell recognize the damage and halt division until it can be fixed? The answer lies in the proteins that package and unravel DNA.
引用
收藏
页码:406 / 407
页数:2
相关论文
共 13 条
  • [1] Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
    Celeste, A
    Fernandez-Capetillo, O
    Kruhlak, MJ
    Pilch, DR
    Staudt, DW
    Lee, A
    Bonner, RF
    Bonner, WM
    Nussenzweig, A
    [J]. NATURE CELL BIOLOGY, 2003, 5 (07) : 675 - U51
  • [2] γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
    Chowdhury, D
    Keogh, MC
    Ishii, H
    Peterson, CL
    Buratowski, S
    Lieberman, J
    [J]. MOLECULAR CELL, 2005, 20 (05) : 801 - 809
  • [3] Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites
    Downs, JA
    Allard, S
    Jobin-Robitaille, O
    Javaheri, A
    Auger, A
    Bouchard, N
    Kron, SJ
    Jackson, SP
    Côté, J
    [J]. MOLECULAR CELL, 2004, 16 (06) : 979 - 990
  • [4] H2AX: the histone guardian of the genome
    Fernandez-Capetillo, O
    Lee, A
    Nussenzweig, M
    Nussenzweig, A
    [J]. DNA REPAIR, 2004, 3 (8-9) : 959 - 967
  • [5] A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
    Keogh, MC
    Kim, JA
    Downey, M
    Fillingham, J
    Chowdhury, D
    Harrison, JC
    Onishi, M
    Datta, N
    Galicia, S
    Emili, A
    Lieberman, J
    Shen, XT
    Buratowski, S
    Haber, JE
    Durocher, D
    Greenblatt, JF
    Krogan, NJ
    [J]. NATURE, 2006, 439 (7075) : 497 - 501
  • [6] Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions
    Kusch, T
    Florens, L
    MacDonald, WH
    Swanson, SK
    Glaser, RL
    Yates, JR
    Abmayr, SM
    Washburn, MP
    Workman, JL
    [J]. SCIENCE, 2004, 306 (5704) : 2084 - 2087
  • [7] INO80 and γ-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair
    Morrison, AJ
    Highland, J
    Krogan, NJ
    Arbel-Eden, A
    Greenblatt, JF
    Haber, JE
    Shen, XT
    [J]. CELL, 2004, 119 (06) : 767 - 775
  • [8] Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
    Murr, R
    Loizou, JI
    Yang, YG
    Cuenin, C
    Li, H
    Wang, ZQ
    Herceg, Z
    [J]. NATURE CELL BIOLOGY, 2006, 8 (01) : 91 - U36
  • [9] DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    Rogakou, EP
    Pilch, DR
    Orr, AH
    Ivanova, VS
    Bonner, WM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) : 5858 - 5868
  • [10] Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break
    Shroff, R
    Arbel-Eden, A
    Pilch, D
    Ira, G
    Bonner, WM
    Petrini, JH
    Haber, JE
    Lichten, M
    [J]. CURRENT BIOLOGY, 2004, 14 (19) : 1703 - 1711