Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

被引:567
作者
Hoffman, SL
Goh, LML
Luke, TC
Schneider, I
Le, TP
Doolan, DL
Sacci, J
de la Vega, P
Dowler, M
Paul, C
Gordon, DM
Stoute, JA
Church, LWP
Sedegah, M
Heppner, DG
Ballou, WR
Richie, TL
机构
[1] Naval Med Res Ctr, Malaria Program, Silver Spring, MD USA
[2] Walter Reed Army Inst Res, Dept Immunol & Entomol, Silver Spring, MD USA
[3] Henry M Jackson Fdn, Rockville, MD USA
[4] Natl Naval Med Ctr, Bethesda, MD USA
[5] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA
[6] Univ Maryland, Sch Med, Dept Microbiol, Baltimore, MD 21201 USA
关键词
D O I
10.1086/339409
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
During 1989-1999, 11 volunteers were immunized by the bites of 1001-2927 irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain NF54 or clone 3D7/NF54. Ten volunteers were first challenged by the bites of Pf-infected mosquitoes 2-9 weeks after the last immunization, and all were protected. A volunteer challenged 10 weeks after the last immunization was not protected. Five previously protected volunteers were rechallenged 23-42 weeks after a secondary immunization, and 4 were protected. Two volunteers were protected when rechallenged with a heterologous Pf strain (7G8). In total, there was protection in 24 of 26 challenges. These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks.
引用
收藏
页码:1155 / 1164
页数:10
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