Comparison between a guaiac and three immunochemical faecal occult blood tests in screening for colorectal cancer

被引：71

作者：

Faivre, J. ^{[1
]}

Dancourt, V. ^{[2
]}

Denis, B. ^{[3
]}

Dorval, E. ^{[4
]}

Piette, C. ^{[5
]}

Perrin, Ph ^{[3
]}

Bidan, J. M. ^{[6
]}

Jard, C. ^{[7
]}

Jung, S. ^{[8
]}

Levillain, R. ^{[9
]}

Viguier, J. ^{[4
]}

Bretagne, J. F. ^{[10
]}

机构：

[1] Univ Bourgogne, Registre Bourguignon Canc Digestifs, CHU Dijon, INSERM,U866, F-21079 Dijon, France

[2] INSERM, Registre Bourguignon Canc Digestifs, U866, F-21000 Dijon, France

[3] ADECA Alsace, F-68008 Colmar, France

[4] CHU Tours, F-37044 Tours 9, France

[5] ADECI 35, F-35000 Rennes, France

[6] CPAM Dijon, Lab CES, F-21000 Dijon, France

[7] CPAM Rennes, Lab CES, F-35000 Rennes, France

[8] CPAM Mulhouse, Lab CES, F-68100 Mulhouse, France

[9] IRSA Tours, Inst Inter Reg Sante, F-37521 La Riche, France

[10] CHU Rennes, F-35000 Rennes, France

来源：

EUROPEAN JOURNAL OF CANCER | 2012年 / 48卷 / 16期

关键词：

Colorectal cancer; Screening; Faecal occult blood tests; AVERAGE-RISK; POPULATION; PERFORMANCE; SURVIVAL; MORTALITY; ACCURACY; FRANCE; NUMBER;

D O I：

10.1016/j.ejca.2012.04.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The aim of this study was to compare the performance of the guaiacbased faecal occult blood test (G-FOBT), with that of three immunochemical faecal occult blood tests (I-FOBT) which allow automatic interpretation. Patients and methods: Under the French organised screening programme, 85,149 average-risk individuals aged 50-74 participating in the third screening round, performed both the G-FOBT (Hemoccult-II test) and one of the I-FOBTs: FOB-Gold, Magstream and OC-Sensor. Results: Given the chosen threshold, the positivity ratio between the different I-FOBTs and the G-FOBT was 2.4 for FOB-Gold, 2.0 for Magstream and 2.2 for OC-Sensor (P = 0.17). The three I- FOBTs were superior to the G-FOBT for colorectal cancer (CRC) detection. The ratios for detection rates were 1.6 (FOB-Gold), 1.7 (Magstream) and 2.1 (OC-Sensor) (P = 0.74). For non-invasive CRC they were, respectively, 2.5, 3.0 and 4.0 (P = 0.83) and for advanced adenomas 3.6, 3.1 and 4.0 (P = 0.39). Conclusions: This study provides further evidence that I-FOBT is superior to G-FOBT. None of the three I-FOBTs studied appeared to be significantly better than the others. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2969 / 2976

页数：8

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