NFAT transcription factors - new players in the pathogenesis of inflammatory arthropathies?

被引：10

作者：

Pessler, F

Dai, L

Cron, RQ

Schumacher, HR

机构：

[1] Childrens Hosp Philadelphia, Div Rheumatol, Dept Pediat, Philadelphia, PA 19104 USA

[2] Sun Yat Sen Univ, Div Rheumatol, Affiliated Hosp 2, Guangzhou 510120, Peoples R China

[3] Univ Penn, Sch Med, Div Rheumatol, Philadelphia, PA 19104 USA

来源：

AUTOIMMUNITY REVIEWS | 2006年 / 5卷 / 02期

关键词：

arthritis; nuclear factor of activated T cells; synovium;

D O I：

10.1016/j.autrev.2005.08.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammatory arthropathies are characterized by major changes in gene expression, which-ultimately-result from differential activities of intracellular signaling pathways and their associated inducible transcription factors. The nuclear factor of activated T cells' (NFAT) family of transcription factors plays diverse roles in a variety of processes in the immune system and other tissues. Preliminary evidence has recently emerged implicating NFAT family members directly in the pathogenesis of inflammatory arthropathies. Specific anti-NFAT drug therapy may add to the pharmacologic armamentarium against rheumatoid arthritis, other inflammatory arthropathies, and related autoimmune disorders. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：106 / 110

页数：5

共 24 条

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