Historical perspective and clinical implications of the Pelger-Huet cell

被引：29

作者：

Cunningham, John M. ^{[1
]}

Patnaik, Mrinal M. ^{[2
]}

Hammerschmidt, Dale E. ^{[3
]}

Vercellotti, Gregory M. ^{[3
]}

机构：

[1] Univ Minnesota Twin Cities, Sch Med, Minneapolis, MN USA

[2] Mayo Clin, Dept Hematol Oncol & Transplantat, Rochester, MN USA

[3] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2009年 / 84卷 / 02期

关键词：

LAMIN-B-RECEPTOR; MYELODYSPLASTIC-SYNDROMES; POLYMORPHONUCLEAR LEUKOCYTES; MYELOID-LEUKEMIA; NUCLEAR LAMINA; THERAPY; GRANULOCYTES; NEUTROPHILS; EXPRESSION; MUTATIONS;

D O I：

10.1002/ajh.21320

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The unique historical aspects of Pelger and Huet's discovery of the Pelger-Huet cell highlight the diagnostic challenge that this morphologic finding presents to the physician. Making the diagnosis of the benign autosomal dominant anomaly is complicated by the morphologically similar pseudo-Pelger-Huet cell, which can signify underlying myeloid dsyplasia. This article relates the history of the Pelger-Huet anomaly as well as describes the clinical significance and diagnostic workup for the finding of a Pelger-Huet cell on peripheral smear. Am. J. Hematol. 84:116-119, 2009. (C) 2008 Wiley-Liss, Inc.

引用

页码：116 / 119

页数：4

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