Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

被引：2339

作者：

Bronte, Vincenzo ^{[1
]}

Brandau, Sven ^{[2
]}

Chen, Shu-Hsia ^{[3
]}

Colombo, Mario P. ^{[4
]}

Frey, Alan B. ^{[5
]}

Greten, Tim F. ^{[6
]}

Mandruzzato, Susanna ^{[7
,8
]}

Murray, Peter J. ^{[9
,10
]}

Ochoa, Augusto ^{[11
]}

Ostrand-Rosenberg, Suzanne ^{[12
]}

Rodriguez, Paulo C. ^{[13
]}

Sica, Antonio ^{[14
,15
]}

Umansky, Viktor ^{[16
,17
]}

Vonderheide, Robert H. ^{[18
]}

Gabrilovich, Dmitry I. ^{[18
,19
]}

机构：

[1] Univ Verona, Univ Hosp, Dept Med, I-37134 Verona, Italy

[2] Univ Hosp Essen, Dept Otorhinolaryngol, D-45122 Essen, Germany

[3] Icahn Sch Med Mt Sinai, Inst Immunol, Tisch Canc Inst, Dept Oncol Sci, New York, NY 10029 USA

[4] Fdn IRCCS Ist Nazl Tumori, Dept Expt Oncol & Mol Med, Mol Immunol Unit, I-20133 Milan, Italy

[5] New York Univ, Sch Med, New York, NY 10029 USA

[6] NCI, Thorac & GI Oncol Branch, GI Malignancy Sect, Bethesda, MD 20892 USA

[7] Univ Padua, Dept Surg Oncol & Gastroenterol, Sect Oncol & Immunol, I-35128 Padua, Italy

[8] IRCCS, Veneto Inst Oncol IOV, I-35128 Padua, Italy

[9] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[10] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[11] Louisiana State Univ, Stanley S Scott Canc Ctr, New Orleans, LA 70112 USA

[12] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA

[13] Georgia Regents Univ, Ctr Canc, Augusta, GA 30912 USA

[14] Humanitas Clin & Res Ctr, Via Manzoni 56, I-20089 Milan, Italy

[15] Univ Piemonte Orientale Amedeo Avogadro, Dept Pharmaceut Sci, Via Bovio 6, I-20089 Novara, Italy

[16] German Canc Res Ctr, Skin Canc Unit, D-69120 Heidelberg, Germany

[17] Ruprecht Karl Univ Heidelberg, Univ Med Ctr Mannheim, Dept Dermatol Venereol & Allergol, D-69120 Mannheim, Germany

[18] Univ Penn, Abramson Canc Ctr, Sch Med, Philadelphia, PA 19104 USA

[19] Wistar Inst Anat & Biol, Translat Tumor Immunol, Philadelphia, PA 19104 USA

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

关键词：

T-CELLS; IMMUNE-RESPONSE; DENDRITIC CELLS; TUMOR-GROWTH; DIFFERENTIATION; INHIBITION; ACCUMULATION; POLARIZATION; MACROPHAGES; SUBSETS;

D O I：

10.1038/ncomms12150

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

引用

页数：10

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