Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator

被引：107

作者：

Sonneborn, A ^{[1
]}

Bockmühl, DP ^{[1
]}

Ernst, JF ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Mikrobiol, D-40225 Dusseldorf, Germany

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 10期

关键词：

D O I：

10.1128/IAI.67.10.5514-5517.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chlamydospore formation of the fungal pathogen Candida albicans was found to depend on the Efg1 protein, which regulates the yeast-hyphal transition. Isogenic mutants lacking EFG1 or encoding T206A and T206E variants did not differentiate chlamydospores, while cek1, cph1, or tpk2 mutations had no effect. Furthermore, filamentation of efg1 cph1 double mutants in microaerophilic conditions suggests a novel Efg1p/Cph1p-independent filamentation pathway in C. albicans.

引用

页码：5514 / 5517

页数：4

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