Phosphatidylserine-mediated adhesion of T-cells to endothelial cells

被引：15

作者：

Qu, JM

Conroy, LA

Walker, JH

Wooding, FBP

Lucy, JA

机构：

[1] BABRAHAM INST,DEPT CELLULAR PHYSIOL,CAMBRIDGE CB2 4AT,ENGLAND

[2] BABRAHAM INST,DEPT IMMUNOL,CAMBRIDGE CB2 4AT,ENGLAND

[3] UNIV LEEDS,DEPT BIOCHEM & MOLEC BIOL,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1996年 / 317卷

关键词：

MEMBRANE PHOSPHOLIPID ASYMMETRY; VASCULAR ENDOTHELIUM; P-SELECTIN; AMINOPHOSPHOLIPID EXPOSURE; ANNEXIN-V; SURFACE; BLOOD; ERYTHROCYTES; VESICULATION; LYMPHOCYTES;

D O I：

10.1042/bj3170343

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatidylserine was exposed on the surface of human umbilical endothelial cells (ECV304) a few minutes after adding thrombin in vitro, as monitored by prothrombinase assays with and without annexin V. Jurkat T cells adhered to the thrombin-treated cells. The adhesion was inhibited by annexin V, indicating that it was mediated by exposed phosphatidylserine on the endothelial cells.

引用

页码：343 / 346

页数：4

共 31 条

[1] SURFACE EXPOSURE OF PHOSPHATIDYLSERINE IS ASSOCIATED WITH THE SWELLING AND OSMOTICALLY-INDUCED FUSION OF HUMAN ERYTHROCYTES IN THE PRESENCE OF CA-2+ [J].