A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

被引：181

作者：

Mato, S

Chevaleyre, V

Robbe, D

Pazos, A

Castillo, PE

Manzoni, OJ

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

[2] Inst Magendie Neurosci, Equipe INSERM Avenir, F-33077 Bordeaux, France

[3] Univ Cantabria, Dept Physiol & Pharmacol, Santander 39011, Cantabria, Spain

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 06期

关键词：

D O I：

10.1038/nn1251

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.

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页码：585 / 586

页数：2

相关论文

共 15 条

[1] Chronic Δ9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain [J].

Breivogel, CS ;

Childers, SR ;

Deadwyler, SA ;

Hampson, RE ;

Vogt, LJ ;

Sim-Selley, LJ .

JOURNAL OF NEUROCHEMISTRY, 1999, 73 (06) :2447-2459

[2] Heterosynaptic LTD of hippocampal GABAergic synapses: A novel role of endocannabinoids in regulating excitability [J].

Chevaleyre, V ;

Castillo, PE .

NEURON, 2003, 38 (03) :461-472

[3] Emerging roles for endocannabinoids in long-term synaptic plasticity [J].

Gerdeman, GL ;

Lovinger, DM .

BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140 (05) :781-789

[4]

Hoffman AF, 2003, J NEUROSCI, V23, P4815

[5] Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with Δ-9-tetrahydrocannabinol [J].

Hutcheson, DM ;

Tzavara, ET ;

Smadja, C ;

Valjent, E ;

Roques, BP ;

Hanoune, J ;

Maldonado, R .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 125 (07) :1567-1577

[6] Study of cannabinoid dependence in animals [J].

Maldonado, R .

PHARMACOLOGY & THERAPEUTICS, 2002, 95 (02) :153-164

[7] Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain [J].

Mato, S ;

Del Olmo, E ;

Pazos, A .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (09) :1747-1754

[8] Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure [J].

Melis, M ;

Camarini, R ;

Ungless, MA ;

Bonci, A .

JOURNAL OF NEUROSCIENCE, 2002, 22 (06) :2074-2082

[9] Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals [J].

Ohno-Shosaku, T ;

Maejima, T ;

Kano, M .

NEURON, 2001, 29 (03) :729-738

[10] Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens [J].

Robbe, D ;

Kopf, M ;

Remaury, A ;

Bockaert, J ;

Manzoni, OJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8384-8388