Genetic polymorphisms of vascular endothelial growth factor and angiopoietin 2 in retinopathy of prematurity

被引：29

作者：

Banyasz, Ilona

Bokodi, Geza

Vannay, Adam

Szebeni, Beata

Treszl, Andras

Vasarhelyi, Barna

Tulassay, Tivadar

Szabo, Andras

机构：

[1] Semmelweis Univ, Dept Paediat 1, H-1083 Budapest, Hungary

[2] Semmelweis Univ, Szentagothai Janos Knowledge Ctr, H-1085 Budapest, Hungary

[3] Hungarian Acad Sci, Res Grp Paediat & Nephrol, Budapest, Hungary

来源：

CURRENT EYE RESEARCH | 2006年 / 31卷 / 7-8期

基金：

匈牙利科学研究基金会;

关键词：

angiopoietin; 2; genetic polymorphism; preterm infant; retinopathy of prematurity; vascular endothelial growth factor;

D O I：

10.1080/02713680600801123

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Angiogenic factors such as vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang2) contribute to development of retinopathy of prematurity (ROP). We aimed to test whether polymorphisms of these factors are associated with ROP. VEGF(-2578) and Ang2(-35) polymorphisms were analyzed with PCR-RFLP method in 200 preterm infants without ROP or with ROP stages 1-5. Our results suggest that there is no association between carrier state of VEGF(-2578) and Ang2(-35) and risk of ROP in preterm infants. The prevalence of VEGF(-2578) "A allele was lower in preterm boys with severe ROP (stages 4-5) than in those without or with mild ROP (stages 1-3).

引用

页码：685 / 690

页数：6

共 17 条

[1] INCREASED THROMBOXANE-MEDIATED CONTRACTIONS OF RETINAL-VESSELS OF NEWBORN PIGS TO PEROXIDES [J].