Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

被引：22

作者：

Battle, Andrew R. ^{[3
]}

Valenzuela, Stella M. ^{[3
]}

Mechler, Adam ^{[1
]}

Nichols, Ryan J. ^{[1
]}

Praporski, Slavica ^{[1
]}

di Maio, Isabelle L. ^{[3
]}

Islam, Hedoyetul ^{[3
]}

Cirard-Egrot, Agnes P. ^{[5
]}

Cornell, Bruce A. ^{[2
]}

Prashar, Jog ^{[4
]}

Caruso, Frank ^{[6
]}

Martin, Lisandra L. ^{[1
]}

Martin, Donald K. ^{[3
]}

机构：

[1] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

[2] Surg Diagnost Ltd, St Leonards, NSW 2065, Australia

[3] Univ Technol Sydney, Fac Sci, Broadway, NSW 2007, Australia

[4] Ambri Pty Ltd, Chatswood, NSW 2063, Australia

[5] Univ Lyon 1, CNRS, INSA Lyon CPE Lyon, ICBMS,Lab Genie Enzymat & Biomol,UMR 5246, F-69622 Villeurbanne, France

[6] Univ Melbourne, Dept Chem & Biomol Engn, Ctr Nanosci & Nanotechnol, Melbourne, Vic 3010, Australia

来源：

ADVANCED FUNCTIONAL MATERIALS | 2009年 / 19卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

MULTILAYERED PARTICLES; CAPSULES; SURFACE;

D O I：

10.1002/adfm.200800483

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules Is reported. A novel engineered ion channel, gramicidin (bis-gA), incorporated Into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.

引用

页码：201 / 208

页数：8

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