Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif

被引：13

作者：

Ueki, N

Seki, N

Yano, K

Masuho, Y

Saito, T

Muramatsu, M

机构：

[1] Helix Res Inst, Biol Technol Lab, Chiba 2920812, Japan

[2] Natl Inst Radiol Sci, Genome Res Grp, Inage Ku, Chiba 2638555, Japan

[3] Tokyo Med & Dent Univ, Med Res Inst, Dept Biol Cybernet, Bunkyo Ku, Tokyo 1138510, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1445卷 / 02期

关键词：

RING finger motif; chromosome; 5q23.3-q31.1; RH mapping; genome structure;

D O I：

10.1016/S0167-4781(99)00045-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A human cDNA, HFB30, encoding a novel protein that contains a RING finger (C3HC4-type zinc finger) motif was isolated. This cDNA clone consists of 3056 nucleotides and encodes an open reading frame of a 474 amino acid protein. From RT-PCR analysis, the messenger RNA was ubiquitously expressed in various human tissues. The gene was located to the chromosome 5q23.3-q31.1 region by PCR-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid mapping panel. Furthermore, the gene consists of nine exons that span about 20 kb of genome DNA. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：232 / 236

页数：5

共 19 条

[1] STRUCTURE OF THE C3HC4 DOMAIN BY H-1-NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY - A NEW STRUCTURAL CLASS OF ZINC-FINGER [J].