Large-scale sequence analysis of avian influenza isolates

被引：477

作者：

Obenauer, JC

Denson, J

Mehta, PK

Su, XP

Mukatira, S

Finkelstein, DB

Xu, XQ

Wang, JH

Ma, J

Fan, YP

Rakestraw, KM

Webster, RG

Hoffmann, E

Krauss, S

Zheng, J

Zhang, ZW

Naeve, CW

机构：

[1] St Jude Childrens Hosp, Hartwell Ctr Bioinformat & Biotechnol, Memphis, TN 38105 USA

[2] St Jude Childrens Hosp, Dept Infect Dis, Div Virol, Memphis, TN 38105 USA

[3] St Jude Childrens Hosp, Dept Biol Struct, Memphis, TN 38105 USA

[4] Univ Tennessee, Ctr Hlth Sci, Dept Pathol, Memphis, TN 38163 USA

来源：

SCIENCE | 2006年 / 311卷 / 5767期

关键词：

D O I：

10.1126/science.1121586

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.

引用

页码：1576 / 1580

页数：5

共 19 条

[1] H5N1 virus outbreak in migratory waterfowl
Chen, H
Smith, GJD
Zhang, SY
Qin, K
Wang, J
Li, KS
Webster, RG
Peiris, JSM
Guan, Y
[J]. NATURE, 2005, 436 (7048) : 191 - 192
[2] A novel influenza A virus mitochondrial protein that induces cell death
Chen, WS
Calvo, PA
Malide, D
Gibbs, J
Schubert, U
Bacik, I
Basta, S
O'Neill, R
Schickli, J
Palese, P
Henklein, P
Bennink, JR
Yewdell, JW
[J]. NATURE MEDICINE, 2001, 7 (12) : 1306 - 1312
[3] Public health - Pandemic flu jitters grip Washington
Enserink, M
[J]. SCIENCE, 2005, 310 (5746) : 209 - 209
[4] Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems
García-Sastre, A
Egorov, A
Matassov, D
Brandt, S
Levy, DE
Durbin, JE
Palese, P
Muster, T
[J]. VIROLOGY, 1998, 252 (02) : 324 - 330
[5] Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells:: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
Geiss, GK
Salvatore, M
Tumpey, TM
Carter, VS
Wang, XY
Basler, CF
Taubenberger, JK
Bumgarner, RE
Palese, P
Katze, MG
García-Sastre, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (16) : 10736 - 10741
[6] Influenza: Lessons from past pandemics, warnings from current incidents
Horimoto, T
Kawaoka, Y
[J]. NATURE REVIEWS MICROBIOLOGY, 2005, 3 (08) : 591 - 600
[7] Influence of host species on the evolution of the nonstructural (NS) gene of influenza A viruses
Kawaoka, Y
Gorman, OT
Ito, T
Wells, K
Donis, RO
Castrucci, MR
Donatelli, I
Webster, RG
[J]. VIRUS RESEARCH, 1998, 55 (02) : 143 - 156
[8] Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein
Krug, RM
Yuan, WM
Noah, DL
Latham, AG
[J]. VIROLOGY, 2003, 309 (02) : 181 - 189
[9] Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses
Lipatov, AS
Andreansky, S
Webby, RJ
Hulse, DJ
Rehg, JE
Krauss, S
Perez, DR
Doherty, PC
Webster, RG
Sangster, MY
[J]. JOURNAL OF GENERAL VIROLOGY, 2005, 86 : 1121 - 1130
[10] Highly pathogenic H5N1 influenza virus infection in migratory birds
Liu, J
Xiao, H
Lei, F
Zhu, Q
Qin, K
Zhang, XW
Zhang, XL
Zhao, D
Wang, G
Feng, Y
Ma, J
Liu, W
Wang, J
Gao, GF
[J]. SCIENCE, 2005, 309 (5738) : 1206 - 1206

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