Large-scale sequence analysis of avian influenza isolates

被引:477
作者
Obenauer, JC
Denson, J
Mehta, PK
Su, XP
Mukatira, S
Finkelstein, DB
Xu, XQ
Wang, JH
Ma, J
Fan, YP
Rakestraw, KM
Webster, RG
Hoffmann, E
Krauss, S
Zheng, J
Zhang, ZW
Naeve, CW
机构
[1] St Jude Childrens Hosp, Hartwell Ctr Bioinformat & Biotechnol, Memphis, TN 38105 USA
[2] St Jude Childrens Hosp, Dept Infect Dis, Div Virol, Memphis, TN 38105 USA
[3] St Jude Childrens Hosp, Dept Biol Struct, Memphis, TN 38105 USA
[4] Univ Tennessee, Ctr Hlth Sci, Dept Pathol, Memphis, TN 38163 USA
关键词
D O I
10.1126/science.1121586
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.
引用
收藏
页码:1576 / 1580
页数:5
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