Germinal Center B Cell Dynamics

被引：699

作者：

Mesin, Luka ^{[1
,2
]}

Ersching, Jonatan ^{[1
,2
]}

Victora, Gabriel D. ^{[1
,2
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] Rockefeller Univ, Lab Lymphocyte Dynam, New York, NY 10065 USA

来源：

IMMUNITY | 2016年 / 45卷 / 03期

关键词：

FOLLICULAR DENDRITIC CELLS; PRIMARY IMMUNE-RESPONSE; REGULATORY T-CELLS; MEMORY B; PLASMA-CELL; AFFINITY MATURATION; IN-VIVO; DARK ZONE; CLONAL SELECTION; ANTIBODY-RESPONSES;

D O I：

10.1016/j.immuni.2016.09.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.

引用

页码：471 / 482

页数：12

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