Low-molecular-weight, calcium-dependent phospholipase a, genes are linked and map to homologous chromosome regions in mouse and human

The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes, All three genes are present in many mammalian species and are expressed in a tissue-specific pattern. Here, we demonstrate in human that they are tightly linked and map to chromosome 1p34-p36.1. We also show that the homologous mouse loci are tightly linked (no observed recombination) on the dis tal part of chromosome 4, a region exhibiting synteny with human 1p34-p36, Unlike its rodent counterpart, human PLA2G2C appears to be a nonfunctional pseudogene. (C) 1996 Academic Press, Inc.