Requirement of fibroblast growth factor 10 in development of white adipose tissue

被引：115

作者：

Sakaue, H

Konishi, M

Ogawa, W

Asaki, T

Mori, T

Yamasaki, M

Takata, M

Ueno, H

Kato, S

Kasuga, M ^{[1
]}

Itoh, N

机构：

[1] Kyoto Univ, Dept Biochem Genet, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan

[2] Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Diabet Digest & Kidney Dis,Chou Ku, Kobe, Hyogo 6500017, Japan

[3] Univ Occupat & Environm Hlth, Sch Med, Dept Biochem & Mol Physiol, Kitakyushu, Fukuoka 8078555, Japan

[4] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

来源：

GENES & DEVELOPMENT | 2002年 / 16卷 / 08期

关键词：

FGF10; adipogenesis; differentiation; C/EBP beta 1;

D O I：

10.1101/gad.983202

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fibroblast growth factors (FGFs) are important intercellular signaling molecules in developmental processes. Here, we show that FGF10 is secreted by cultured preadipocytes and that prevention of FGF10 signaling inhibits the expression of C/EBPbeta and the subsequent differentiation of these cells. An active form of C/EBPbeta rescued differentiation of the cells in which FGF10 signaling was blocked. Development of white adipose tissue and the expression of C/EBPbeta in this tissue of FGF10 knockout mice were markedly reduced, and the ability of embryonic fibroblasts derived from FGF10 knockout mice to differentiate into adipocytes was impaired. Therefore, FGF10 plays an important role in adipogenesis, at least partly by contributing to the expression of C/EBPbeta through an autocrine/paracrine mechanism.

引用

页码：908 / 912

页数：5

共 31 条

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