Epidermal nerve fiber quantification in the assessment of diabetic neuropathy

被引：100

作者：

Beiswenger, Kristina K. ^{[1
]}

Calcutt, Nigel A. ^{[1
]}

Mizisin, Andrew P. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

来源：

ACTA HISTOCHEMICA | 2008年 / 110卷 / 05期

关键词：

intraepidermal nerve fiber; diabetic neuropathy; cutaneous innervation; skin;

D O I：

10.1016/j.acthis.2007.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Assessment of cutaneous innervation in skin biopsies is emerging as a vatuable means of both diagnosing and staging diabetic neuropathy. Immunotabeting, using antibodies to neuronal proteins such as protein gene product 9.5, allows for the visualization and quantification of intraepidermal nerve fibers. Multiple studies have shown reductions in intraepidermal nerve fiber density in skin biopsies from patients with both type 1 and type 2 diabetes. More recent studies have focused on correlating these changes with other measures of diabetic neuropathy. A toss of epidermal innervation similar to that observed in diabetic patients has been observed in rodent models of both type 1 and type 2 diabetes and several therapeutics have been reported to prevent reductions in intraepidermal nerve fiber density in these models. This review discusses the current literature describing diabetes-induced changes in cutaneous innervation in both human and animal models of diabetic neuropathy. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：351 / 362

页数：12

共 77 条

[1]

Beiswenger K, 2007, J PERIPHER NERV SYST, V12, P8

[2] Erythropoietin both protects from and reverses experimental diabetic neuropathy [J].

Bianchi, R ;

Buyukakilli, B ;

Brines, M ;

Savino, C ;

Cavaletti, G ;

Oggioni, N ;

Lauria, G ;

Borgna, M ;

Lombardi, R ;

Cimen, B ;

Comelekoglu, U ;

Kanik, A ;

Tataroglu, C ;

Cerami, A ;

Ghezzi, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (03) :823-828

[3]

BJORKLUND H, 1986, CELL TISSUE RES, V243, P51

[4] Severe depletion of intraepidermal nerve fibers in skin biopsies of pancreas transplant recipients [J].

Boucek, P ;

Havrdova, T ;

Voska, L ;

Lodererova, A ;

Saudek, F ;

Lipar, K ;

Janousek, L ;

Adamec, M ;

Sommer, C .

TRANSPLANTATION PROCEEDINGS, 2005, 37 (08) :3574-3575

[5] The expression of P2X3 purinoreceptors in sensory neurons:: Effects of axotomy and glial-derived neurotrophic factor [J].

Bradbury, EJ ;

Burnstock, G ;

McMahon, SB .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1998, 12 (4-5) :256-268

[6] The capsaicin receptor: a heat-activated ion channel in the pain pathway [J].

Caterina, MJ ;

Schumacher, MA ;

Tominaga, M ;

Rosen, TA ;

Levine, JD ;

Julius, D .

NATURE, 1997, 389 (6653) :816-824

[7] Prolonged preservation of nerve function in diabetic neuropathy in mice by herpes simplex virus-mediated gene transfer [J].

Chattopadhyay, M. ;

Mata, M. ;

Goss, J. ;

Wolfe, D. ;

Huang, S. ;

Glorioso, J. C. ;

Fink, D. J. .

DIABETOLOGIA, 2007, 50 (07) :1550-1558

[8] HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy [J].

Chattopadhyay, M ;

Krisky, D ;

Wolfe, D ;

Glorioso, JC ;

Mata, M ;

Fink, DJ .

GENE THERAPY, 2005, 12 (18) :1377-1384

[9] Noninvasive monitoring of diabetes-induced cutaneous nerve fiber loss and hypoalgesia in thy1-YFP transgenic mice [J].

Chen, YS ;

Chung, SSM ;

Chung, SK .

DIABETES, 2005, 54 (11) :3112-3118

[10] Restorative effects of neurotrophin treatment on diabetes-induced cutaneous axon loss in mice [J].

Christianson, JA ;

Riekhof, JT ;

Wright, DE .

EXPERIMENTAL NEUROLOGY, 2003, 179 (02) :188-199

← 1 2 3 4 5 6 7 8 →