Role of chemokines polymorphisms in diseases

被引：34

作者：

Guergnon, J. ^{[1
]}

Combadiere, C. ^{[1
,2
]}

机构：

[1] Univ Paris 06, INSERM, UMRS 945, Lab Immun & Infect, F-75013 Paris, France

[2] Grp Hosp Pitie Salpetriere, AP HP, Serv Immunol, F-75634 Paris, France

来源：

IMMUNOLOGY LETTERS | 2012年 / 145卷 / 1-2期

关键词：

Chemokines; Polymorphisms; Infectious diseases; Inflammation; Cancer; Cardiovascular diseases; Auto-immunity; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MCP-1 GENE POLYMORPHISM; DUFFY-BLOOD-GROUP; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE LYMPHOBLASTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; THAN-A POLYMORPHISM; CD4(+) T-CELLS; PROMOTER POLYMORPHISM; COPY NUMBER;

D O I：

10.1016/j.imlet.2012.04.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interest into chemokine polymorphisms came with the discovery of allelic variants of HIV co-receptors (CCR5 and CXCR4 mainly) that confers protection against virus entry into usual permissive cells. Since then, chemokines genetic background has been deeply studied in order to find associations between allelic variants and inflammation-related diseases as well as infectious diseases. In addition to HIV infection, chemokines genetic variations have been involved in other infectious diseases as HCV, Malaria and West Nile Virus, and also in a variety of non-infectious diseases such as cancer, auto-immune and cardiovascular diseases. This review aims to present genetic variations in chemokines encoding genes and discuss their role, sometimes controversial, in a variety of diseases. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：15 / 22

页数：8

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