Leucyl-tRNA synthetase: double duty in amino acid sensing

被引：13

作者：

Duran, Raul V. ^{[1
]}

Hall, Michael N. ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

CELL RESEARCH | 2012年 / 22卷 / 08期

关键词：

CONTROLS TORC1; EGO COMPLEX; RAG GTPASES; MTORC1; ACTIVATION; REGULATOR; PATHWAY;

D O I：

10.1038/cr.2012.68

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.

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收藏

页码：1207 / 1209

页数：3

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